Techniques and circuitry are provided for programmably controlling signal offsets in integrated circuitry. In one embodiment, an integrated circuit includes a signal offset cancellation circuit that is programmably selected to control the offset of signals on either one input/output or another input/output of an amplifier circuit. In one embodiment, a logic circuit is used to selectively couple a bank of current sources to one input/output or another input/output of a differential amplifier through a switching circuit. The bank of current sources may employed to control the signal offset on either input/output, or may be decoupled from all of the inputs/outputs when signal offset cancellation is not required.