发明授权
US07371570B2 Cell-specific adenovirus vector comprising EBV-specific promoter
失效
包含EBV特异性启动子的细胞特异性腺病毒载体
- 专利标题： Cell-specific adenovirus vector comprising EBV-specific promoter
- 专利标题（中）： 包含EBV特异性启动子的细胞特异性腺病毒载体
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申请号： US10698160申请日： 2003-10-30
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公开(公告)号： US07371570B2公开(公告)日： 2008-05-13
- 发明人: De Chao Yu , Nagarajan Ramesh
- 申请人： De Chao Yu , Nagarajan Ramesh
- 申请人地址： US CA South Francisco
- 专利权人： Cell Genesys, Inc.
- 当前专利权人： Cell Genesys, Inc.
- 当前专利权人地址： US CA South Francisco
- 代理机构： Ropes & Gray, LLP
- 代理商 James F. Haley, Jr.
- 主分类号： C12N15/861
- IPC分类号： C12N15/861 ; C12N5/10 ; A61K48/00
摘要：
Replication-competent adenoviral vectors comprising an EBV-specific transcriptional regulatory element (TRE) operably linked to a gene required for adenovirus replication are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication can be restricted to particular target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity for treating neoplasia.