发明授权
US07375105B2 Pyridine substituted furan derivatives as Raf kinase inhibitors
失效
吡啶取代的呋喃衍生物作为Raf激酶抑制剂
- 专利标题： Pyridine substituted furan derivatives as Raf kinase inhibitors
- 专利标题（中）： 吡啶取代的呋喃衍生物作为Raf激酶抑制剂
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申请号： US10488650申请日： 2002-09-05
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公开(公告)号： US07375105B2公开(公告)日： 2008-05-20
- 发明人: David Kenneth Dean , Andrew Kenneth Takle , David Matthew Wilson
- 申请人： David Kenneth Dean , Andrew Kenneth Takle , David Matthew Wilson
- 申请人地址： GB Brentford, Middlesex
- 专利权人： SmithKline Beecham p.l.c.
- 当前专利权人： SmithKline Beecham p.l.c.
- 当前专利权人地址： GB Brentford, Middlesex
- 代理商 Grace C. Hsu; Mary E. McCarthy; Charles M. Kinzig
- 优先权： GB0121485.7 20010905; GB0121493.1 20010905
- 国际申请： PCT/EP02/09944 WO 20020905
- 国际公布： WO03/022838 WO 20030320
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/4545 ; A61K31/443 ; C07D413/14 ; C07D211/32 ; C07D405/04
摘要：
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. Wherein X is O, CH2 CO, S or NH, or the moiety X—R1 is hydrogen; Y1 and Y2 independently represent CH or N; Ar is a mono- or fused bicyclic aromatic or heteroaromatic group which may be optionally substituted; one of X1 and X2 is selected from O, S or NR11 and the other is CH, wherein R11 is hydrogen, C1-6alkyl, aryl or arylC1-6alkyl.
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