发明授权
- 专利标题： Modulation of Aurora B expression
- 专利标题（中）： 调节极光B表达
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申请号： US11136815申请日： 2005-05-24
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公开(公告)号： US07375212B2公开(公告)日： 2008-05-20
- 发明人: Nicholas M. Dean , Kenneth W. Dobie , Erich Koller
- 申请人： Nicholas M. Dean , Kenneth W. Dobie , Erich Koller
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Knobbe, Martens, Olson and Bear LLP
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04 ; A61K31/70
摘要：
Compounds, compositions and methods are provided for modulating the expression of Aurora B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Aurora B. Methods of using these compounds for modulation of Aurora B expression and for diagnosis and treatment of diseases and conditions associated with expression of Aurora B are provided. Also provided are methods of using these compounds to modulate the growth of cancer cells, including p53-deficient cancer cells.
公开/授权文献
- US20050267065A1 Modulation of Aurora B expression 公开/授权日：2005-12-01
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