公开(公告)号：US07375212B2

公开(公告)日：2008-05-20

申请号：US11136815

申请日：2005-05-24

申请人： Nicholas M. Dean ,  Kenneth W. Dobie ,  Erich Koller

发明人： Nicholas M. Dean ,  Kenneth W. Dobie ,  Erich Koller

IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K31/70

CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y207/01037 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of Aurora B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Aurora B. Methods of using these compounds for modulation of Aurora B expression and for diagnosis and treatment of diseases and conditions associated with expression of Aurora B are provided. Also provided are methods of using these compounds to modulate the growth of cancer cells, including p53-deficient cancer cells.

摘要翻译： 提供化合物，组合物和方法用于调节Aurora B的表达。组合物包含靶向编码Aurora B的核酸的寡核苷酸。使用这些化合物调节Aurora B表达并用于诊断和治疗与 提供极光B的表达。 还提供了使用这些化合物调节癌细胞（包括p53缺陷型癌细胞）生长的方法。

公开(公告)号：US07718628B2

公开(公告)日：2010-05-18

申请号：US11618167

申请日：2006-12-29

申请人： Kenneth W. Dobie ,  Erich Koller

发明人： Kenneth W. Dobie ,  Erich Koller

IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K31/70 ,  C12N5/00 ,  C12Q1/68

CPC分类号： C12N15/113 ,  A01K2267/0331 ,  A61K31/711 ,  A61K31/713 ,  A61K48/00 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525 ,  C12N2310/3521

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding kinesin-like 1. Methods of using these compounds for modulation of kinesin-like 1 expression and for treatment of diseases associated with expression of kinesin-like 1 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节驱动蛋白样1的表达。组合物包含靶向编码驱动蛋白样物质的核酸的反义化合物，特别是反义寡核苷酸1.使用这些化合物调节驱动蛋白样1 提供表达和用于治疗与驱动蛋白样1的表达相关的疾病。

公开(公告)号：US08470795B2

公开(公告)日：2013-06-25

申请号：US12714361

申请日：2010-02-26

申请人： Kenneth W. Dobie ,  Erich Koller

发明人： Kenneth W. Dobie ,  Erich Koller

IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K31/70 ,  C12N5/00 ,  C12Q1/68

CPC分类号： C12N15/113 ,  A01K2267/0331 ,  A61K31/711 ,  A61K31/713 ,  A61K48/00 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525 ,  C12N2310/3521

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding kinesin-like 1. Methods of using these compounds for modulation of kinesin-like 1 expression and for treatment of diseases associated with expression of kinesin-like 1 are provided.

公开(公告)号：US20100240738A1

公开(公告)日：2010-09-23

申请号：US12714361

申请日：2010-02-26

申请人： Kenneth W. Dobie ,  Erich Koller

发明人： Kenneth W. Dobie ,  Erich Koller

IPC分类号： A61K31/7088 ,  C07H21/04 ,  A61P35/00

CPC分类号： C12N15/113 ,  A01K2267/0331 ,  A61K31/711 ,  A61K31/713 ,  A61K48/00 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525 ,  C12N2310/3521

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding kinesin-like 1. Methods of using these compounds for modulation of kinesin-like 1 expression and for treatment of diseases associated with expression of kinesin-like 1 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节驱动蛋白样1的表达。组合物包含靶向编码驱动蛋白样物质的核酸的反义化合物，特别是反义寡核苷酸1.使用这些化合物调节驱动蛋白样1 提供表达和用于治疗与驱动蛋白样1的表达相关的疾病。

公开(公告)号：US07199107B2

公开(公告)日：2007-04-03

申请号：US10714796

申请日：2003-11-17

申请人： Kenneth W. Dobie ,  Erich Koller

发明人： Kenneth W. Dobie ,  Erich Koller

IPC分类号： A61K31/70 ,  C07H21/04 ,  C07H21/02 ,  C12N5/00 ,  C12Q1/68

CPC分类号： C12N15/113 ,  A01K2267/0331 ,  A61K31/711 ,  A61K31/713 ,  A61K48/00 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525 ,  C12N2310/3521

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding kinesin-like 1. Methods of using these compounds for modulation of kinesin-like 1 expression and for treatment of diseases associated with expression of kinesin-like 1 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节驱动蛋白样1的表达。组合物包含靶向编码驱动蛋白样物质的核酸的反义化合物，特别是反义寡核苷酸1.使用这些化合物调节驱动蛋白样1 提供表达和用于治疗与驱动蛋白样1的表达相关的疾病。

公开(公告)号：US07163927B2

公开(公告)日：2007-01-16

申请号：US10156603

申请日：2002-05-23

申请人： Kenneth W. Dobie ,  Erich Koller

发明人： Kenneth W. Dobie ,  Erich Koller

IPC分类号： A61K31/70 ,  C07H21/04 ,  C07H21/02 ,  C12N5/00 ,  C12Q1/68

CPC分类号： C12N15/1137 ,  A01K2267/0331 ,  A61K48/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3521

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding kinesin-like 1. Methods of using these compounds for modulation of kinesin-like 1 expression and for treatment of diseases associated with expression of kinesin-like 1 are provided.

公开(公告)号：US07683036B2

公开(公告)日：2010-03-23

申请号：US10909125

申请日：2004-07-30

申请人： Christine Esau ,  Bridget Lollo ,  C. Frank Bennett ,  Susan M. Freier ,  Richard H. Griffey ,  Brenda F. Baker ,  Timothy A. Vickers ,  Eric G. Marcusson ,  Erich Koller ,  Eric E. Swayze ,  Ravi Jain ,  Balkrishen Bhat ,  Eigen Peralta

发明人： Christine Esau ,  Bridget Lollo ,  C. Frank Bennett ,  Susan M. Freier ,  Richard H. Griffey ,  Brenda F. Baker ,  Timothy A. Vickers ,  Eric G. Marcusson ,  Erich Koller ,  Eric E. Swayze ,  Ravi Jain ,  Balkrishen Bhat ,  Eigen Peralta

IPC分类号： A61K31/70 ,  C07H21/04

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/31 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/3181 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/50 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.

摘要翻译： 提供化合物，组合物和方法用于调节小非编码RNA的表达和功能。 组合物包含靶向小的非编码RNA的寡聚化合物。 还提供了使用这些化合物调节小非编码RNA以及这些RNA的下游靶标以及用于诊断和治疗与小非编码RNA相关的疾病的方法。

公开(公告)号：US20090291907A1

公开(公告)日：2009-11-26

申请号：US12345891

申请日：2008-12-30

申请人： Christine Esau ,  Bridget Lollo ,  C. Frank Bennett ,  Susan M. Freier ,  Richard H. Griffey ,  Brenda F. Baker ,  Timothy A. Vickers ,  Eric G. Marcusson ,  Erich Koller ,  Eric E. Swayze ,  Ravi Jain ,  Balkrishen Bhat ,  Eigen Peralta

发明人： Christine Esau ,  Bridget Lollo ,  C. Frank Bennett ,  Susan M. Freier ,  Richard H. Griffey ,  Brenda F. Baker ,  Timothy A. Vickers ,  Eric G. Marcusson ,  Erich Koller ,  Eric E. Swayze ,  Ravi Jain ,  Balkrishen Bhat ,  Eigen Peralta

IPC分类号： A61K31/7105 ,  C12N5/06 ,  C12Q1/68

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/31 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/3181 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/50 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.

摘要翻译： 提供化合物，组合物和方法用于调节小非编码RNA的表达和功能。 组合物包含靶向小的非编码RNA的寡聚化合物。 还提供了使用这些化合物调节小非编码RNA以及这些RNA的下游靶标以及用于诊断和治疗与小非编码RNA相关的疾病的方法。

公开(公告)号：US20050215504A1

公开(公告)日：2005-09-29

申请号：US11014360

申请日：2004-12-16

申请人： C. Bennett ,  Susan Freier ,  Nicholas Dean ,  Brett Monia ,  William Gaarde ,  James Karras ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  Lex Cowsert ,  Erich Koller ,  Jacqueline Wyatt ,  Mark Roach ,  Andrew Watt ,  Brenda Baker ,  Kenneth Dobie

发明人： C. Bennett ,  Susan Freier ,  Nicholas Dean ,  Brett Monia ,  William Gaarde ,  James Karras ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  Lex Cowsert ,  Erich Koller ,  Jacqueline Wyatt ,  Mark Roach ,  Andrew Watt ,  Brenda Baker ,  Kenneth Dobie

IPC分类号： A61K48/00 ,  C07H21/02 ,  C12N15/113 ,  C12Q1/68

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节甾醇调节元件结合蛋白-1的表达。 组合物包含靶向编码固醇调节元件结合蛋白-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节固醇调节元件结合蛋白-1表达和治疗与甾醇调节元件结合蛋白-1的表达相关的疾病的方法。

公开(公告)号：US5576676A

公开(公告)日：1996-11-19

申请号：US592825

申请日：1996-01-26

申请人： Erich Koller ,  Hans Weichert ,  Daniel Zumkeller

发明人： Erich Koller ,  Hans Weichert ,  Daniel Zumkeller

IPC分类号： H01H50/02 ,  H01H50/04 ,  H01H50/08 ,  H01H50/14 ,  H01H50/44 ,  H05K3/32 ,  H05K3/40 ,  H01H67/02

CPC分类号： H01H50/047 ,  H01H50/08 ,  H01H50/14 ,  H01H50/021 ,  H05K3/325 ,  H05K3/4007

摘要： The base plate module of an electromagnetic switching device, specifically a contactor, is mounted on a base plate (1). The base plate module contains the core (2) of the electromagnet, a magnet coil (5), a printed circuit board (10) with its connected ancillary devices, as well as the contact plugs (16, 17) and terminals (24, 25), both of which are accessible from the outside. Printed circuit board (10) is mounted on base plate (1) and is located between base plate (1) and core (2), which is mounted on the base plate. Strip conductors (12, 13, 14), on the side facing core (2), feature several spring-loaded stub contacts (19, 20) and/or contact plugs (21, 22), all of which are vertically mounted on circuit board (10). Flange (7) of coil module (6), which is oriented toward base plate (1), provided with terminals (23) of magnet coil (5). With magnet coil (5) in the mounted position, terminals (23) of magnet coil (5) are in contact with the spring-loaded stub contacts (19) of strip conductors (13). Contact plugs (21, 22) serve as receptacles for card (27) which contains electronic circuitry. All electrical connections in the base plate module are made by strip conductors (12, 13, 14) of printed circuit board (10).

摘要翻译： 电磁开关装置的基板模块，特别是接触器，安装在基板（1）上。 基板模块包含电磁铁的芯（2），电磁线圈（5），具有连接的辅助装置的印刷电路板（10）以及接触插塞（16,17）和端子（24， 25），这两个都可以从外面访问。 印刷电路板（10）安装在基板（1）上，位于安装在基板上的基板（1）和芯（2）之间。 在面向铁芯（2）的一侧上的带状导体（12,13,14）具有几个弹簧加载的短截线触头（19,20）和/或接触插头（21,22），所有这些垂直安装在电路 板（10）。 线圈模块（6）的朝向基板（1）的方向（7）设置有电磁线圈（5）的端子（23）。 在电磁线圈（5）处于安装位置时，电磁线圈（5）的端子（23）与带状导体（13）的弹簧加载短截线触点（19）接触。 接触塞（21,22）用作卡（27）的插座，其包含电子电路。 基板模块中的所有电连接由印刷电路板（10）的带状导体（12,13,14）制成。