Invention Grant
US07378251B2 Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a thioredoxin-like 32 kDa protein
有权
鉴定使用硫氧还蛋白样32kDa蛋白调节IL-4受体介导的IgE合成的化合物的方法
- Patent Title: Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a thioredoxin-like 32 kDa protein
- Patent Title (中): 鉴定使用硫氧还蛋白样32kDa蛋白调节IL-4受体介导的IgE合成的化合物的方法
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Application No.: US10197962Application Date: 2002-07-16
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Publication No.: US07378251B2Publication Date: 2008-05-27
- Inventor: Esteban Masuda , Todd M. Kinsella , Justin E. Warner , Taisei Kinoshita , Mark K. Bennett , David C. Anderson
- Applicant: Esteban Masuda , Todd M. Kinsella , Justin E. Warner , Taisei Kinoshita , Mark K. Bennett , David C. Anderson
- Applicant Address: US CA South San Francisco
- Assignee: Rigel Pharmaceuticals, Inc.
- Current Assignee: Rigel Pharmaceuticals, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent James J. Diehl; James S. Keddie; Carol L. Francis
- Main IPC: G01N33/53
- IPC: G01N33/53
Abstract:
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a thioredoxin-like 32 kDa protein (TXNL) as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
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