公开(公告)号：US07422867B2

公开(公告)日：2008-09-09

申请号：US11784176

申请日：2007-04-04

Applicant: Esteban Masuda ,  Todd M. Kinsella ,  Justin E. Warner ,  Taisei Kinoshita ,  Mark K. Bennett ,  David C. Anderson

Inventor： Esteban Masuda ,  Todd M. Kinsella ,  Justin E. Warner ,  Taisei Kinoshita ,  Mark K. Bennett ,  David C. Anderson

IPC: C12Q1/37

CPC classification number: C07K7/08 ,  A61K38/1709 ,  C07K14/5406 ,  G01N33/6869 ,  G01N2333/5406 ,  G01N2500/00 ,  Y10S435/975

Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

公开(公告)号：US07378251B2

公开(公告)日：2008-05-27

申请号：US10197962

申请日：2002-07-16

Applicant: Esteban Masuda ,  Todd M. Kinsella ,  Justin E. Warner ,  Taisei Kinoshita ,  Mark K. Bennett ,  David C. Anderson

Inventor： Esteban Masuda ,  Todd M. Kinsella ,  Justin E. Warner ,  Taisei Kinoshita ,  Mark K. Bennett ,  David C. Anderson

IPC: G01N33/53

CPC classification number: G01N33/6854 ,  A61K38/00

Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a thioredoxin-like 32 kDa protein (TXNL) as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

Abstract translation: 本发明提供了能够调节IL-4受体介导的IgE产生的化合物以及与其相关的IL-4诱导的过程，用于鉴定利用硫氧还蛋白样32kDa蛋白（TXNL）作为替代分析物的化合物的方法和试剂盒 以及在各种体外和体外上下文中使用化合物的方法。

公开(公告)号：US07241581B2

公开(公告)日：2007-07-10

申请号：US10222729

申请日：2002-08-16

Applicant: Esteban Masuda ,  Todd M. Kinsella ,  Justin E. Warner ,  Taisei Kinoshita ,  Mark K. Bennett ,  David C. Anderson

Inventor： Esteban Masuda ,  Todd M. Kinsella ,  Justin E. Warner ,  Taisei Kinoshita ,  Mark K. Bennett ,  David C. Anderson

IPC: G01N33/566 ,  G01N33/53 ,  G01N33/542 ,  A61K38/20 ,  A61K45/00

CPC classification number: C07K14/4703 ,  A61K38/1709 ,  G01N33/6854 ,  G01N2333/5406

Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a c-Myc protein as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

Abstract translation: 本发明提供了能够调节IL-4受体介导的IgE产生的化合物以及与其相关的IL-4诱导的过程，用于鉴定利用c-Myc蛋白作为替代分析物的这些化合物的方法和试剂盒以及使用 化合物在各种体外，体外和体外上下文中。

公开(公告)号：US06979549B2

公开(公告)日：2005-12-27

申请号：US10197368

申请日：2002-07-16

Applicant: Esteban Masuda ,  Todd M. Kinsella ,  Justin E. Warner ,  Taisei Kinoshita ,  Mark K. Bennett ,  David C. Anderson

Inventor： Esteban Masuda ,  Todd M. Kinsella ,  Justin E. Warner ,  Taisei Kinoshita ,  Mark K. Bennett ,  David C. Anderson

IPC: A61K38/17 ,  C07K7/08 ,  C07K14/54 ,  G01N33/68 ,  G01N33/567 ,  A61K38/00 ,  C12Q1/52 ,  G01N33/53

CPC classification number: C07K7/08 ,  A61K38/1709 ,  C07K14/5406 ,  G01N33/6869 ,  G01N2333/5406 ,  G01N2500/00 ,  Y10S435/975

Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

Abstract translation: 本发明提供能够调节IL-4受体介导的IgE产生的化合物以及与其相关的IL-4诱导的过程，用于鉴定利用CLLD8蛋白作为替代分析物的化合物的方法和试剂盒以及使用该化合物的方法 各种体外，体外和体外上下文。

公开(公告)号：US06568421B2

公开(公告)日：2003-05-27

申请号：US10135907

申请日：2002-04-29

Applicant: David C. Anderson

Inventor： David C. Anderson

IPC: F16L5916

CPC classification number: E03C1/102 ,  Y10T137/7036 ,  Y10T137/7062

Abstract: A pressure vacuum breaker cover assembly for protecting a vacuum breaker while simultaneously improving the appearance. The inventive device includes a pair of covers having a shell structure attachable to one another about a vacuum breaker. Each of the covers includes a lip that mates with the opposing cover lip, a plurality of apertures that allow the securing of the covers together with a conventional fastener, a lower cutout for receiving a lower pipe, and a side cutout for receiving an upper pipe from the vacuum breaker. The covers are preferably constructed of a STYROFOAM or polyfoam material for insulating and protecting the vacuum breaker and pipes. The exterior surface of the covers may be painted to match the exterior of the building structure.

公开(公告)号：US06184356B2

公开(公告)日：2001-02-06

申请号：US09058562

申请日：1998-04-13

Applicant: David C. Anderson ,  Antony J. Mathews ,  Gary L. Stetler

Inventor： David C. Anderson ,  Antony J. Mathews ,  Gary L. Stetler

IPC: C07K14805

CPC classification number: C12N15/81 ,  A61K38/00 ,  A61K47/6445 ,  C07K14/805 ,  C07K2319/00 ,  C07K2319/50 ,  C07K2319/92 ,  Y10S530/829

Abstract: DNA molecules which encode pseudodimeric globin-like polypeptides with an asymmetric cysteine mutation suitable for crosslinking two tetramers, or which encode pseudooligomeric globin-like polypeptides comprising four or more globin-like domains, are useful in the preparation of multimeric hemoglobin-like proteins.

Abstract translation: 编码具有适用于交联两个四聚体的不对称半胱氨酸突变的伪二聚球蛋白样多肽的DNA分子或编码包含四个或更多个珠蛋白样结构域的假寡聚寡核苷酸样多肽的DNA分子可用于制备多聚体血红蛋白样蛋白。

公开(公告)号：US6090585A

公开(公告)日：2000-07-18

申请号：US474553

申请日：1995-06-07

Applicant: David F. Carmichael ,  David C. Anderson ,  George P. Stricklin ,  Howard G. Welgus

Inventor： David F. Carmichael ,  David C. Anderson ,  George P. Stricklin ,  Howard G. Welgus

IPC: C12N9/99 ,  A61K38/00 ,  A61P43/00 ,  C07H21/04 ,  C07K14/00 ,  C07K14/24 ,  C07K14/245 ,  C07K14/81 ,  C12N9/64 ,  C12N15/00 ,  C12N15/09 ,  C12N15/62 ,  C12N15/70 ,  C12P21/00 ,  C12P21/02 ,  C12R1/125 ,  C12R1/19 ,  C12R1/385 ,  C12R1/865 ,  C12R1/91 ,  C12N15/63

CPC classification number: C07K14/8146 ,  C07K14/24 ,  C07K14/245 ,  C12N15/70 ,  A61K38/00 ,  C07K2319/02

Abstract: A portable DNA sequence is disclosed which is capable of directing intracellular production of metalloproteinanse inhibitors. Vectors containing this portable DNA sequence are also set forth, including the vector pUC9-F5/237P10 (ATCC Accession No. 53003). A recombinant-DNA method for the microbial production of a metalloproteinase inhibitor, which method incorporates at least one of the portable DNA sequences and the vectors disclosed herein is described.

Abstract translation: 公开了能够引导细胞内产生金属蛋白酶抑制剂的便携式DNA序列。 还载有含有该携带DNA序列的载体，包括载体pUC9-F5 / 237P10（ATCC登录号53003）。 描述了一种用于微生物产生金属蛋白酶抑制剂的重组DNA方法，该方法结合了本文公开的至少一种便携式DNA序列和载体。

公开(公告)号：US5844089A

公开(公告)日：1998-12-01

申请号：US450733

申请日：1995-05-25

Applicant: Stephen J. Hoffman ,  Douglas L. Looker ,  Mary S. Rosendahl ,  Gary L. Stetler ,  Michael Wagenbach ,  David C. Anderson ,  Antony James Mathews ,  Kiyoshi Nagai

Inventor： Stephen J. Hoffman ,  Douglas L. Looker ,  Mary S. Rosendahl ,  Gary L. Stetler ,  Michael Wagenbach ,  David C. Anderson ,  Antony James Mathews ,  Kiyoshi Nagai

IPC: A61K38/16 ,  A61K38/00 ,  A61K47/48 ,  A61P7/08 ,  C07K20060101 ,  C07K1/113 ,  C07K14/805 ,  C12N15/00 ,  C12N15/09 ,  C12N15/12 ,  C12N15/81 ,  C12P21/02 ,  C12R1/19 ,  C12R1/91

CPC classification number: C07K14/805 ,  A61K47/48307 ,  C12N15/81 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/50 ,  C07K2319/92

Abstract: The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained.

Abstract translation: 在本文中，血红蛋白的α亚基本质上被形成为与β-亚基非共价结合的分离的多肽链，这里以新分子二-α球蛋白的形式提供，单链多肽链通过将两个α亚基连接而定义 直接通过肽键或通过柔性氨基酸或肽接头间接。 Di-α珠蛋白可以在体内或体外与β球蛋白和血红素组合以形成血红蛋白。 Di-α球蛋白通过重组DNA技术表达。 可以类似地获得二β-珠蛋白。

公开(公告)号：USRE35780E

公开(公告)日：1998-05-05

申请号：US326174

申请日：1994-10-19

Applicant: David A. Hassell ,  David C. Anderson

Inventor： David A. Hassell ,  David C. Anderson

IPC: B01F15/02 ,  B67D1/00 ,  B67D1/10 ,  B67D1/12 ,  F04C2/12 ,  G05D11/00 ,  B67D5/56

CPC classification number: G05D11/005 ,  B01F15/0218 ,  B67D1/0031 ,  B67D1/0037 ,  B67D1/107 ,  B67D1/12 ,  F04C2/126 ,  G05D11/008 ,  Y10T137/2516

Abstract: The present invention is a post-mix beverage dispensing valve for accurately maintaining the proper ratio of two liquid beverage components. The present invention includes a valve main body having a gear pump secured thereto. The gear pump includes two sets of oval gears. One set of oval gears is in fluid communication with a source of pressurized carbonated water, and the second set is in fluid communication with a source of syrup. The valve body also includes solenoid operated pallet valves for each of the beverage components. Ratioing of the solenoid provides for simultaneous opening of both pallet valves whereby the pressurized carbonated water flows between the carbonated water gears and is swept thereby through the valve body to the dispensing nozzle. One gear of each gear pair is secured to a common rotating shaft. Pressurized carbonated water provides for the rotation of the syrup gears, thereby providing for the pumping of the syrup to the nozzle. The gear pairs are sized so that the desired ratio between the beverage components is maintained.

Abstract translation: 本发明是用于精确地保持两种液体饮料组分的适当比例的后混合饮料分配阀。 本发明包括具有固定在其上的齿轮泵的阀主体。 齿轮泵包括两套椭圆形齿轮。 一组椭圆形齿轮与加压碳酸水源流体连通，第二组与糖浆源流体连通。 阀体还包括用于每个饮料部件的电磁操作的托盘阀。 螺线管的比例提供了两个托盘阀的同时打开，由此加压的碳酸水在碳酸水齿轮之间流动并且被扫过，从而通过阀体到达分配喷嘴。 每个齿轮对的一个齿轮固定到共同的转轴上。 加压的碳酸水提供糖浆齿轮的旋转，从而提供将糖浆泵送到喷嘴。 齿轮对的尺寸使得维持饮料部件之间所需的比例。

公开(公告)号：US5717058A

公开(公告)日：1998-02-10

申请号：US199508

申请日：1994-02-18

Applicant: Maura-Ann H. Matthews ,  Gary L. Stetler ,  Spencer J. Anthony-Cahill ,  David C. Anderson

Inventor： Maura-Ann H. Matthews ,  Gary L. Stetler ,  Spencer J. Anthony-Cahill ,  David C. Anderson

IPC: A61K38/00 ,  A61K48/00 ,  C07K14/02 ,  C07K14/15 ,  C12N15/67 ,  C07K14/155 ,  C07K4/02 ,  C07K5/00 ,  C07K7/00

CPC classification number: C07K14/005 ,  C12N15/67 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2730/10122 ,  C12N2740/14022

Abstract: The present invention relates to regulators of cellular gene transcription, particularly inhibitors of cellular gene transactivating factors and in particular to inhibition of gene transcription in a viral host cell that is subject to regulation by proteins or factors that originate from a virus as well as conjugates or fusion products of the inhibitors and internalization molecules, pharmaceutical compositions that can be used to alleviate or prevent the manifestation of disease states that are the result of unregulated DNA transcription as a result of transactivation, methods of treating diseases that are caused or exacerbated by the presence of transactivating factors, and regulated gene therapy to achieve long term drug delivery of the inhibitors of the present invention. This invention can be applied both to cells with genetic abnormalities or to cells infected with a virus. Preferably, at least one protein of the protein-protein interactions is a transactivating factor.

Abstract translation: 本发明涉及细胞基因转录的调节剂，特别是细胞基因反式激活因子的抑制剂，特别是抑制病毒宿主细胞中的基因转录，所述基因转录受来自病毒的蛋白质或因子的调节，以及缀合物或 抑制剂和内化分子的融合产物，可用于缓解或预防作为反式激活导致的不受调节的DNA转录的结果的疾病状态的表现的药物组合物，治疗由于存在引起或加剧的疾病的方法 的转录因子和调节基因治疗以实现本发明的抑制剂的长期药物递送。 本发明可以应用于具有遗传异常的细胞或用于感染病毒的细胞。 优选地，蛋白质 - 蛋白质相互作用的至少一种蛋白质是反式激活因子。