发明授权
- 专利标题： NF-kappaB oligonucleotide decoy molecules
- 专利标题（中）： NF-κB寡核苷酸诱饵分子
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申请号： US11004512申请日： 2004-12-02
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公开(公告)号： US07378509B2公开(公告)日： 2008-05-27
- 发明人: Leslie M. McEvoy , Christi Parham , Jie Zhang , Rolf Ehrhardt
- 申请人： Leslie M. McEvoy , Christi Parham , Jie Zhang , Rolf Ehrhardt
- 申请人地址： US CA South San Francisco
- 专利权人： Anesiva, Inc.
- 当前专利权人： Anesiva, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Goodwin Procter LLP
- 代理商 Christopher De Vry; Ginger R. Dreger
- 主分类号： C07H21/04
- IPC分类号： C07H21/04
摘要：
The present invention concerns double-stranded NF-κB decoy oligodeoxynucleotide (NF-κB dsODN) molecules that contain a core sequence capable of specific binding to an NF-κB transcription factor. In a particular aspect, the invention concerns NF-κB decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF-κB decoy molecules with improved binding affinity to p65.
公开/授权文献
- US20050182012A1 NF-kappaB oligonucleotide decoy molecules 公开/授权日：2005-08-18
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