公开(公告)号：US12131895B2

公开(公告)日：2024-10-29

申请号：US17717505

申请日：2022-04-11

申请人： Micromass UK Limited

发明人： John Brian Hoyes ,  Boris Kozlov

IPC分类号： H01J49/40 ,  H01J49/06 ,  H01J49/42

CPC分类号： H01J49/401 ,  H01J49/061 ,  H01J49/406 ,  H01J49/408 ,  H01J49/4245

摘要： A Time of Flight mass analyser is disclosed comprising: at least one ion mirror 34 for reflecting ions; an ion detector 36 arranged for detecting the reflected ions; a first pulsed ion accelerator 30 for accelerating an ion packet in a first dimension (Y-dimension) towards the ion detector 36 so that the ion packet spatially converges in the first dimension as it travels to the detector 36; and a pulsed orthogonal accelerator 32 for orthogonally accelerating the ion packet in a second, orthogonal dimension (X-dimension) into one of said at least one ion mirrors 34.

公开(公告)号：US12121967B2

公开(公告)日：2024-10-22

申请号：US17683899

申请日：2022-03-01

申请人： Carpenter Technology Corporation

发明人： Francis William Herbert ,  John Robert Rushton ,  Nicholas Paul Weeks ,  Ben Ian Ferrar ,  Christopher Wooder ,  Philip Anthony Carroll

IPC分类号： B22F10/73 ,  B22F10/80 ,  B22F12/58 ,  B33Y10/00 ,  B33Y40/10 ,  B33Y50/00

CPC分类号： B22F10/73 ,  B22F10/80 ,  B22F12/58 ,  B33Y10/00 ,  B33Y40/10 ,  B33Y50/00

摘要： Closed-loop metal powder management methods for additive manufacturing. Virgin metal powder is provided in a closed powder container comprising at least one sensor, tracker, or optical device. The metal powder is transferred to an additive manufacturing system, a portion of a metal powder layer is consolidated, and excess metal powder is transferred from the additive manufacturing system to the powder container, a second powder container, or an internal powder container. Virgin metal powder or a second metal powder are added to the excess metal powder, a quality of the mixed powder is validated, the process is repeated at least once, and powder physical transfer data associated with at least one of the steps is collected and stored in a data repository. Powder material parameters may be measured and assessed, and may be also be stored in the data repository.

公开(公告)号：US12110283B2

公开(公告)日：2024-10-08

申请号：US17372029

申请日：2021-07-09

申请人： VisEn Medical, Inc.

发明人： Kevin Groves ,  Bagna Bao

IPC分类号： C07D401/06 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K49/00 ,  C07D209/14 ,  C07D209/60 ,  C07D401/14 ,  C07D417/14 ,  C09B23/01 ,  C09B23/08 ,  G01N21/64 ,  G01N33/58

CPC分类号： C07D401/06 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/0052 ,  C07D209/14 ,  C07D209/60 ,  C07D401/14 ,  C07D417/14 ,  C09B23/0008 ,  C09B23/0033 ,  C09B23/083 ,  C09B23/086 ,  G01N21/6458 ,  G01N33/582 ,  G01N2333/988 ,  Y02A50/30

摘要： The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.

公开(公告)号：USD1044827S1

公开(公告)日：2024-10-01

申请号：US29778481

申请日：2021-04-13

申请人： Recentive Analytics, Inc.

设计人： Andysheh Tabrizi ,  Evan Charles Smith

摘要： The FIGURE is a front view of a display screen with a graphical user interface, according to a first embodiment.
The dashed broken lines, including all text shown, illustrate portions of the graphical user interface that form no part of the claimed design.

公开(公告)号：US12097352B2

公开(公告)日：2024-09-24

申请号：US17412729

申请日：2021-08-26

申请人： Insulet Corporation

发明人： Jason O'Connor ,  Matthew Alles ,  Robert Sanzone ,  Craig Brodeur ,  Joseph Melo ,  Christopher Williams ,  Noel Schaeffer

IPC分类号： A61M5/142

CPC分类号： A61M5/14244 ,  A61M2005/14208 ,  A61M2005/14252 ,  A61M2205/18 ,  A61M2205/3327 ,  A61M2205/3553 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/584

摘要： The disclosed embodiments are directed to a wearable automatic drug delivery device configured to provide basal-only dosing of insulin. In a primary embodiment, the wearable drug delivery device is configured to provide automatic operation and provides audible alerts and visual status indicators to the patient. In other embodiments, the patient may have some degree of control over the operation of the device by providing tapping gestures on housing of the device. In yet another embodiment, the patient may provide input and receive status from the device via an application executing on a portable computing device in wireless communication with the wearable drug delivery device.

公开(公告)号：US12096081B2

公开(公告)日：2024-09-17

申请号：US16793205

申请日：2020-02-18

申请人： JBF Interlude 2009 LTD

发明人： Jonathan Bloch ,  Tal Zubalsky ,  Yuval Hofshy ,  Barak Feldman

IPC分类号： H04N7/173 ,  H04N21/4402 ,  H04N21/442 ,  H04N21/466 ,  H04N21/8545

CPC分类号： H04N21/4667 ,  H04N21/4402 ,  H04N21/44218 ,  H04N21/8545

摘要： Methods and supporting systems collect data associated with interactive videos user engagement and dynamically adapt an interactive video application and/or interactive video content and detect anomalous behaviors based on the data.

公开(公告)号：US12090301B2

公开(公告)日：2024-09-17

申请号：US16404456

申请日：2019-05-06

申请人： Insulet Corporation

发明人： Jason O'Connor ,  Joon Bok Lee ,  Trang Ly ,  Yibin Zheng ,  Thomas Arnold Peyser ,  Jennifer Lena Schneider

IPC分类号： A61M5/172 ,  A61B5/00 ,  A61B5/145 ,  A61M5/142 ,  A61M5/145

CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61M5/14244 ,  A61M5/145 ,  A61B5/486 ,  A61B5/6832 ,  A61M2005/14208 ,  A61M2005/14252 ,  A61M2205/18 ,  A61M2205/52 ,  A61M2230/201

摘要： Disclosed are a system, methods and computer-readable medium products that provide safety constraints for an insulin-delivery management program. Various examples provide safety constraints for a control algorithm-based drug delivery system that provides automatic delivery of a drug based on sensor input. Glucose measurement values may be received at regular time intervals from a sensor. A processor may predict future glucose values based on prior glucose measurement values. The safety constraints assist in safe operation of the drug delivery system during various operational scenarios. In some examples, predicted future glucose values may be used to implement safety constraints that mitigate under-delivery or over-delivery of the drug while not overly burdening the user of the drug delivery system and without sacrificing performance of the drug delivery system. Other safety constraints are also disclosed.

公开(公告)号：US12084414B2

公开(公告)日：2024-09-10

申请号：US17506276

申请日：2021-10-20

申请人： eXIthera Pharmaceuticals, Inc.

发明人： Robert A. Chrusciel ,  Robert C. Gadwood ,  Neil J. Hayward ,  Michael J. Melnick ,  Manuel A. Navia ,  Toni J. Poel ,  Frans L. Stassen ,  Catherine A. Stewart

IPC分类号： C07D205/08 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/06 ,  C07D417/06 ,  C07D417/14

CPC分类号： C07D205/08 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/06 ,  C07D417/06 ,  C07D417/14

摘要： The present invention provides compounds and compositions that inhibit Factor XIa or kallikrein and methods of using these compounds and composition.

公开(公告)号：US12079347B2

公开(公告)日：2024-09-03

申请号：US17710168

申请日：2022-03-31

申请人： BitSight Technologies, Inc.

发明人： Daniel Dahlberg ,  Stephen Boyer ,  Philip John Steuart Gladstone

IPC分类号： G06F21/57

CPC分类号： G06F21/577 ,  G06F2221/034

摘要： Methods and systems are provide for assessing the cybersecurity state of entities based on extended-computer network characteristics. A method can include obtaining, for a plurality of computer networks associated with an entity and not associated with the entity, a first and second network dataset. The first and second network datasets can be combined. A plurality of Internet Protocol (IP) addresses associated with the entity and associated with a plurality of entities can be obtained, where the entity and the plurality of entities each associated with a unique identifier (UID). The method can include determining whether each of the plurality of computer networks not associated with the entity comprises a remote office network. A cybersecurity state of the entity can be determined based on an evaluation of security characteristics of the IP addresses associated with the entity and of one or more IP addresses attributed to the remote office networks.

公开(公告)号：US12074019B2

公开(公告)日：2024-08-27

申请号：US17437707

申请日：2020-03-11

申请人： Micromass UK Limited

发明人： Martin Raymond Green ,  David J. Langridge

IPC分类号： H01J49/42 ,  H01J49/00

CPC分类号： H01J49/4215 ,  H01J49/0031 ,  H01J49/429

摘要： A method of operating a quadrupole device (10) is disclosed. A voltage source (12) applies a main quadrupolar voltage, an auxiliary quadrupolar voltage and a dipolar voltage to the quadrupole device (10). This may be done such that only ions corresponding to a single X-band, X-band-like, Y-band or Y-band-like stability region are transmitted by the quadrupole device (10).