发明授权
US07390803B2 Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity
失效
趋化因子受体活性的四氢吡喃基环戊基苄基酰胺调节剂
- 专利标题： Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity
- 专利标题（中）： 趋化因子受体活性的四氢吡喃基环戊基苄基酰胺调节剂
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申请号： US10533326申请日： 2003-10-24
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公开(公告)号： US07390803B2公开(公告)日： 2008-06-24
- 发明人: Gabor Butora , Sander G. Mills , Alexander Pasternak , Kothandaraman Shankaran , Lihu Yang , Changyou Zhou , Stephen D. Goble
- 申请人： Gabor Butora , Sander G. Mills , Alexander Pasternak , Kothandaraman Shankaran , Lihu Yang , Changyou Zhou , Stephen D. Goble
- 申请人地址： US NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 James L. McGinnis; Mark Daniel
- 国际申请： PCT/US03/33972 WO 20031024
- 国际公布： WO2004/041161 WO 20040521
- 主分类号： A61K31/351
- IPC分类号： A61K31/351 ; A61K31/4523 ; A61K31/5365 ; C07D257/04 ; C07D231/56
摘要：
The present invention is directed to compounds of the formula (I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28, R29, R30, R31, X, m, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2
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