发明授权
![Aryl-isoxazol-4-yl-imidazo[1,5-a]pyridine derivatives](/docs/US/2008-07-15/US07399769B2/abs.jpg.600x600.jpg)
- 专利标题： Aryl-isoxazol-4-yl-imidazo[1,5-a]pyridine derivatives
- 专利标题（中）： 芳基异恶唑-4-基 - 咪唑并[1,5-a]吡啶衍生物
-
申请号： US11640768申请日： 2006-12-18
-
公开(公告)号： US07399769B2公开(公告)日： 2008-07-15
- 发明人: Bernd Buettelmann , Jiaqiang Dong , Bo Han , Henner Knust , Andrew Thomas
- 申请人： Bernd Buettelmann , Jiaqiang Dong , Bo Han , Henner Knust , Andrew Thomas
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权： EP05112988 20051227
- 主分类号： A61K31/4353
- IPC分类号： A61K31/4353 ; C07D471/02
![Aryl-isoxazol-4-yl-imidazo[1,5-a]pyridine derivatives](/abs-image/US/2008/07/15/US07399769B2/abs.jpg.150x150.jpg)
摘要：
The present invention is concerned with aryl-isoxazol-4-yl-imidazo[1,5-a]pyridine derivatives of formula wherein: R1, R2, and R3 are as defined herein and pharmaceutically acceptable acid addition salts thereof. These compounds have high affinity and selectivity for GABA A α5 receptor binding sites. The invention also relates to methods for enhancing cognition and treating cognitive disorders like Alzheimer's disease.
公开/授权文献
- US20070191421A1 Aryl-isoxazol-4-yl-imidazo[1,5-a]pyridine derivatives 公开/授权日：2007-08-16
信息查询
