发明授权
US07399773B2 Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid and phenylamide
失效
合成5-（4-氟苯基）-1- [2 - （（2R，4R）-4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙基] -2-异丙基-4 - 苯基-1H-吡咯-3-甲酸和苯基酰胺
![Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid and phenylamide](/docs/US/2008-07-15/US07399773B2/abs.jpg.600x600.jpg)
- 专利标题： Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid and phenylamide
- 专利标题（中）： 合成5-（4-氟苯基）-1- [2 - （（2R，4R）-4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙基] -2-异丙基-4 - 苯基-1H-吡咯-3-甲酸和苯基酰胺
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申请号： US11545870申请日： 2006-10-11
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公开(公告)号： US07399773B2公开(公告)日： 2008-07-15
- 发明人: Jade Douglas Nelson , Michael Gerard Pamment
- 申请人： Jade Douglas Nelson , Michael Gerard Pamment
- 申请人地址： US NJ Morris Plains
- 专利权人： Warner-Lambert Company
- 当前专利权人： Warner-Lambert Company
- 当前专利权人地址： US NJ Morris Plains
- 代理商 Gregg C. Benson; B. Timothy Creagan
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; A61K31/4025 ; C07D401/12 ; C07D403/12
![Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid and phenylamide](/abs-image/US/2008/07/15/US07399773B2/abs.jpg.150x150.jpg)
摘要：
An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
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