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![Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d] pryimidin-7-ones](/abs-image/US/2010/08/24/US07781583B2/abs.jpg.150x150.jpg)
1.发明授权Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d] pryimidin-7-ones 失效2-（吡啶-2-基氨基） - 吡啶并[2,3-d]哒嗪-7-酮的合成公开(公告)号：US07781583B2
公开(公告)日：2010-08-24
申请号：US11852873
申请日：2007-09-10
IPC分类号： C07D471/04 , C07D487/04 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention provides methods of preparing substituted 2-(pyridin-2-ylamino)-pirido[2,3-d]pyrimidin-7-ones (formula 1), useful in treating cell proliferative disorders, or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供制备可用于治疗细胞增殖性疾病的取代的2-（吡啶-2-基氨基） - 吡啶并[2,3-d]嘧啶-7-酮（式1）的方法或其药学上可接受的盐。
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![SYNTHESIS OF 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3-d] PRYIMIDIN-7-ONES](/abs-image/US/2008/05/29/US20080125588A1/abs.jpg.150x150.jpg)
2.发明申请SYNTHESIS OF 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3-d] PRYIMIDIN-7-ONES 失效2-（吡啶-2-基）氨基] - 吡咯并[2,3-d]嘧啶-7-酮的合成公开(公告)号：US20080125588A1
公开(公告)日：2008-05-29
申请号：US11852873
申请日：2007-09-10
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides methods of preparing substituted 2-(pyridin-2-ylamino)-pirido[2,3-d]pyrimidin-7-ones (formula 1), useful in treating cell proliferative disorders, or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供制备可用于治疗细胞增殖性疾病的取代的2-（吡啶-2-基氨基） - 吡啶并[2,3-d]嘧啶-7-酮（式1）的方法或其药学上可接受的盐。
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![Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide](/abs-image/US/2008/04/22/US07361771B2/abs.jpg.150x150.jpg)
3.发明授权Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide 失效合成5-（4-氟苯基）-1- [2 - （（2R，4R）-4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙基] -2-异丙基-4 - 苯基-1H-吡咯-3-甲酸苯基酰胺公开(公告)号：US07361771B2
公开(公告)日：2008-04-22
申请号：US11546047
申请日：2006-10-11
申请人： Donald Eugene Butler , Randall Lee Dejong , Jade Douglas Nelson , Michael Gerard Pamment , Timothy Lee Stuk
发明人： Donald Eugene Butler , Randall Lee Dejong , Jade Douglas Nelson , Michael Gerard Pamment , Timothy Lee Stuk
IPC分类号： C07D405/02
CPC分类号： C07D295/185 , C07D207/34 , C07D207/416 , C07D405/06
摘要： An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
摘要翻译： 制备5-（4-氟苯基）-1- [2 - （（2R，4R）-4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙基] -2-异丙基的改进方法 描述了通过新的合成的4-苯基-1H-吡咯-3-羧酸苯基酰胺，其中将氰基乙酸甲酯转化为八个或更少的操作至所需产物，以及在该方法中使用的其它有价值的中间体。
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![Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide](/abs-image/US/2007/02/27/US07183408B2/abs.jpg.150x150.jpg)
4.发明授权Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide 失效合成5-（4-氟苯基）-1- [2 - （（2R，4R）-4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙基] -2-异丙基-4 - 苯基-1H-吡咯-3-甲酸苯基酰胺公开(公告)号：US07183408B2
公开(公告)日：2007-02-27
申请号：US11109396
申请日：2005-04-19
申请人： Donald Eugene Butler , Randall Lee DeJong , Jade Douglas Nelson , Michael Gerard Pamment , Timothy Lee Stuk
发明人： Donald Eugene Butler , Randall Lee DeJong , Jade Douglas Nelson , Michael Gerard Pamment , Timothy Lee Stuk
IPC分类号： C07D413/06 , C07D401/06 , C07D406/06
CPC分类号： C07D295/185 , C07D207/34 , C07D207/416 , C07D405/06
摘要： An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
摘要翻译： 制备5-（4-氟苯基）-1- [2 - （（2R，4R）-4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙基] -2-异丙基的改进方法 描述了通过新的合成的4-苯基-1H-吡咯-3-羧酸苯基酰胺，其中将氰基乙酸甲酯转化为八个或更少的操作至所需产物，以及在该方法中使用的其它有价值的中间体。
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![Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid and phenylamide](/abs-image/US/2008/07/15/US07399773B2/abs.jpg.150x150.jpg)
5.发明授权Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid and phenylamide 失效合成5-（4-氟苯基）-1- [2 - （（2R，4R）-4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙基] -2-异丙基-4 - 苯基-1H-吡咯-3-甲酸和苯基酰胺公开(公告)号：US07399773B2
公开(公告)日：2008-07-15
申请号：US11545870
申请日：2006-10-11
IPC分类号： A61K31/4439 , A61K31/4025 , C07D401/12 , C07D403/12
CPC分类号： C07D295/185 , C07D207/34 , C07D207/416 , C07D405/06
摘要： An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
摘要翻译： 制备5-（4-氟苯基）-1- [2 - （（2R，4R）-4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙基] -2-异丙基的改进方法 描述了通过新的合成的4-苯基-1H-吡咯-3-羧酸苯基酰胺，其中将氰基乙酸甲酯转化为八个或更少的操作至所需产物，以及在该方法中使用的其它有价值的中间体。
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![Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide](/abs-image/US/2008/05/13/US07371855B2/abs.jpg.150x150.jpg)
公开(公告)号：US07371855B2
公开(公告)日：2008-05-13
申请号：US11545899
申请日：2006-10-11
IPC分类号： C07D265/30 , C07D405/00
CPC分类号： C07D295/185 , C07D207/34 , C07D207/416 , C07D405/06
摘要： An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
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![Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide](/abs-image/US/2003/04/08/US06545153B1/abs.jpg.150x150.jpg)
公开(公告)号：US06545153B1
公开(公告)日：2003-04-08
申请号：US10198682
申请日：2002-07-18
申请人： Donald Eugene Butler , Randall Lee Dejong , Jade Douglas Nelson , Michael Gerard Pamment , Timothy Lee Stuk
发明人： Donald Eugene Butler , Randall Lee Dejong , Jade Douglas Nelson , Michael Gerard Pamment , Timothy Lee Stuk
IPC分类号： C07D41306
CPC分类号： C07D295/185 , C07D207/34 , C07D207/416 , C07D405/06
摘要： An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
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![Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide](/abs-image/US/2002/11/05/US06476235B2/abs.jpg.150x150.jpg)
8.发明授权Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide 失效合成5-（4-氟苯基）-1- [2 - （（2R，4R）-4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙基] -2-异丙基-4 - 苯基-1H-吡咯-3-甲酸苯基酰胺公开(公告)号：US06476235B2
公开(公告)日：2002-11-05
申请号：US10015558
申请日：2001-12-17
申请人： Donald Eugene Butler , Randall Lee DeJong , Jade Douglas Nelson , Michael Gerard Pamment , Timothy Lee Stuk
发明人： Donald Eugene Butler , Randall Lee DeJong , Jade Douglas Nelson , Michael Gerard Pamment , Timothy Lee Stuk
IPC分类号： C07D40506
CPC分类号： C07D295/185 , C07D207/34 , C07D207/416 , C07D405/06
摘要： An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
摘要翻译： 制备5-（4-氟苯基）-1- [2 - （（2R，4R）-4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙基] -2-异丙基的改进方法 描述了通过新的合成的4-苯基-1H-吡咯-3-羧酸苯基酰胺，其中将氰基乙酸甲酯转化为八个或更少的操作至所需产物，以及在该方法中使用的其它有价值的中间体。
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