发明授权
US07399778B2 Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
失效
含有唑类的β-淀粉样蛋白产生的杂环磺酰胺抑制剂
- 专利标题: Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
- 专利标题(中): 含有唑类的β-淀粉样蛋白产生的杂环磺酰胺抑制剂
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申请号: US11035005申请日: 2005-01-13
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公开(公告)号: US07399778B2公开(公告)日: 2008-07-15
- 发明人: Lynn Resnick , Donna M. Huryn , Joan E. Sabalski , Joshua D. Berkowitz , Anthony Frank Kreft , Dennis Martin Kubrak , Thomas Joseph Caggiano , Koi Michele Morris
- 申请人: Lynn Resnick , Donna M. Huryn , Joan E. Sabalski , Joshua D. Berkowitz , Anthony Frank Kreft , Dennis Martin Kubrak , Thomas Joseph Caggiano , Koi Michele Morris
- 申请人地址: US NJ Madison
- 专利权人: Wyeth
- 当前专利权人: Wyeth
- 当前专利权人地址: US NJ Madison
- 代理机构: Howson & Howson LLP
- 代理商 Rebecca R. Barrett
- 主分类号: A61K31/415
- IPC分类号: A61K31/415 ; C07D233/00
摘要:
Compounds useful for lowering beta amyloid levels are provided. The compounds have the structure of formula Ia: wherein, R1 is lower alkyl, substituted lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, benzyloxy, substituted benzyloxy, or SO2R5; R5 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, alkyl, or substituted alkyl; R2 is lower alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, or cycloalkyl; R3 is hydrogen, lower alkyl, or substituted lower alkyl; R4 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, thiophene, or substituted thiophene; R6 is hydrogen, lower alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, cycloalkyl, or substituted cycloalkyl; W, X and Y are independently CR7 or N; and R7 is hydrogen, halogen, lower alkyl, or substituted lower alkyl.