发明授权
- 专利标题： Lentiviral vectors for site-specific gene insertion
- 专利标题（中）： 用于位点特异性基因插入的慢病毒载体
-
申请号： US11121354申请日： 2005-05-03
-
公开(公告)号： US07402436B2公开(公告)日： 2008-07-22
- 发明人: Jiing-Kuan Yee , Gilles Michel
- 申请人： Jiing-Kuan Yee , Gilles Michel
- 申请人地址： US CA Duarte
- 专利权人： City of Hope
- 当前专利权人： City of Hope
- 当前专利权人地址： US CA Duarte
- 代理机构： Perkins Coie LLP
- 代理商 Michael J. Wise
- 主分类号： C12N15/63
- IPC分类号： C12N15/63 ; C12N15/64 ; C12N15/867 ; C07K14/155 ; C07K14/195 ; C07K19/00 ; A61K48/00
摘要：
Murine leukemia virus (MLV) and lentivirus vectors have been used previously to deliver genes to hematopoietic stem cells (HSCs) in human gene therapy trials. However, these vectors integrate randomly into the host genome, leading to disruption or inactivation of vital host genes. The present invention discloses a novel lentiviral vector system that overcomes this problem by integrating into a host genome in a site-specific manner.
公开/授权文献
信息查询
IPC分类:
