发明授权
US07414136B2 Method for producing 3-substituted 2-chloro-5-fluoro-pyridine or its salt
失效
制备3-取代的2-氯-5-氟 - 吡啶或其盐的方法
- 专利标题: Method for producing 3-substituted 2-chloro-5-fluoro-pyridine or its salt
- 专利标题(中): 制备3-取代的2-氯-5-氟 - 吡啶或其盐的方法
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申请号: US11265179申请日: 2005-11-03
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公开(公告)号: US07414136B2公开(公告)日: 2008-08-19
- 发明人: Yasushi Matsumura , Nobuaki Mori , Yasuhiro Yamada
- 申请人: Yasushi Matsumura , Nobuaki Mori , Yasuhiro Yamada
- 申请人地址: JP Tokyo
- 专利权人: Asahi Glass Company, Limited
- 当前专利权人: Asahi Glass Company, Limited
- 当前专利权人地址: JP Tokyo
- 代理机构: Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
- 优先权: JP2003-132137 20030509
- 主分类号: C07D213/85
- IPC分类号: C07D213/85 ; C07D213/80
摘要:
To provide a method for producing a 3-substituted 2-chloro-5-fluoro-pyridine or its salt in high yield from a readily available material through a short process under mild reaction conditions using a reagent which is easy for handling and simple in the reaction operation. Namely, a method for producing the following compound (2) or its salt which comprises selectively reducing a chlorine atom at the 6-position of the following compound (1) or its salt, is provided. Further, a method for producing the following compound (4) or its salt which comprises substituting a Z1 group of the following compound (2) or its salt obtained by the reduction reaction, by a Z2 group, is provided. Here, Z1 is —CO2R1, etc., and R1 is a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an aralkyl group or a cycloalkyl group. Z2 is a group different from Z1 and is —CO2R5, etc., and R5 is an alkyl group, an alkenyl group, an aryl group, an aralkyl group or a cycloalkyl group.
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