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    Method for producing 3-substituted 2-chloro-5-fluoro-pyridine or its salt
    1.
    发明授权
    Method for producing 3-substituted 2-chloro-5-fluoro-pyridine or its salt 失效
    制备3-取代的2-氯-5-氟 - 吡啶或其盐的方法

    公开(公告)号：US07414136B2

    公开(公告)日：2008-08-19

    申请号：US11265179

    申请日：2005-11-03

    申请人： Yasushi Matsumura ,  Nobuaki Mori ,  Yasuhiro Yamada

    发明人： Yasushi Matsumura ,  Nobuaki Mori ,  Yasuhiro Yamada

    IPC分类号： C07D213/85 ,  C07D213/80

    CPC分类号： C07D213/80

    摘要： To provide a method for producing a 3-substituted 2-chloro-5-fluoro-pyridine or its salt in high yield from a readily available material through a short process under mild reaction conditions using a reagent which is easy for handling and simple in the reaction operation. Namely, a method for producing the following compound (2) or its salt which comprises selectively reducing a chlorine atom at the 6-position of the following compound (1) or its salt, is provided. Further, a method for producing the following compound (4) or its salt which comprises substituting a Z1 group of the following compound (2) or its salt obtained by the reduction reaction, by a Z2 group, is provided. Here, Z1 is —CO2R1, etc., and R1 is a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an aralkyl group or a cycloalkyl group. Z2 is a group different from Z1 and is —CO2R5, etc., and R5 is an alkyl group, an alkenyl group, an aryl group, an aralkyl group or a cycloalkyl group.

    摘要翻译： 提供一种通过使用容易处理的试剂在温和的反应条件下通过短时间过程从容易获得的材料以高产率制备3-取代的2-氯-5-氟 - 吡啶或其盐的方法， 反应操作。 即，提供了下述化合物（1）或其盐选择性还原6-位的氯原子的下述化合物（2）或其盐的制造方法。 此外，制备下列化合物（4）或其盐的方法，该方法包括用下列化合物（2）或其还原反应得到的盐代替Z 2 组。 这里，Z 1是-CO 2 R 1等，R 1是氢原子， 烷基，烯基，芳基，芳烷基或环烷基。 Z 2是与Z 1不同的基团，并且是-CO 2 R 5等，R 2 烷基，烯基，芳基，芳烷基或环烷基。

    Process for producing (4E)-5-chloro-2-isopropyl-4-pentenoate and optically active form thereof
    3.
    发明授权
    Process for producing (4E)-5-chloro-2-isopropyl-4-pentenoate and optically active form thereof 有权
    制备（4E）-5-氯-2-异丙基-4-戊烯酸酯及其光学活性形式的方法

    公开(公告)号：US07232925B2

    公开(公告)日：2007-06-19

    申请号：US11147255

    申请日：2005-06-08

    申请人： Nobuaki Mori ,  Yasushi Matsumura ,  Yoshitomi Morizawa ,  Toshihiko Kaminuma ,  Yuuichi Aoki

    发明人： Nobuaki Mori ,  Yasushi Matsumura ,  Yoshitomi Morizawa ,  Toshihiko Kaminuma ,  Yuuichi Aoki

    IPC分类号： C07C69/62

    CPC分类号： C07C67/343 ,  C07B2200/07 ,  C07B2200/09 ,  C07C67/32 ,  C07C67/48 ,  C07C69/65

    摘要： The present invention provides processes for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate and an optical isomer of the (4E)-5-chloro-2-isopropyl-4-pentenoate, namely a process for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate represented by the following formula (4), which comprises reacting a compound represented by the following formula (2) in the presence of an aprotic solvent (II) with a base (II) and then with (1E)-1,3-dichloro-1-propene to give a compound represented by the following formula (3), and dealkoxycarbonylating either ester in the compound represented by the following formula (3), and a process for producing a (S)-(4E)-5-chloro-2-isopropyl-4-pentenoate represented by the following formula (5), which comprises optically resolving a (4E)-5-chloro-2-isopropyl-4-pentenoate represented by the formula (4) obtained by the above-mentioned process (wherein R is a lower alkyl group or an aralkyl group).

    摘要翻译： 本发明提供了（4E）-5-氯-2-异丙基-4-戊烯酸酯和（4E）-5-氯-2-异丙基-4-戊烯酸酯的旋光异构体的制备方法，即制备 由下式（4）表示的（4E）-5-氯-2-异丙基-4-戊烯酸酯，其包括使下式（2）表示的化合物在非质子溶剂（II）的存在下与 碱（II），然后与（1E）-1,3-二氯-1-丙烯反应，得到由下式（3）表示的化合物，和由下式（3）表示的化合物中的任一酯脱甲基羰基化，和 一种制备由下式（5）表示的（S） - （4E）-5-氯-2-异丙基-4-戊烯酸酯的方法，该方法包括光学拆分（4E）-5-氯-2-异丙基-4-戊烯酸 由上述方法（其中R是低级烷基或芳烷基）得到的式（4）表示的4-戊烯酸酯。

    PROCESSES FOR PRODUCING (4E)-5-CHLORO-2-ISOPROPYL-4-PENTENOATE AND OPTICALLY ACTIVE FORM THEREOF
    4.
    发明申请
    PROCESSES FOR PRODUCING (4E)-5-CHLORO-2-ISOPROPYL-4-PENTENOATE AND OPTICALLY ACTIVE FORM THEREOF 审中-公开
    制备（4E）-5-氯-2-异丙基-4-丁烯酸的方法及其光学活性形式

    公开(公告)号：US20070191630A1

    公开(公告)日：2007-08-16

    申请号：US11691873

    申请日：2007-03-27

    申请人： Toshitsugu Sakaeda ,  Nobuaki Mori ,  Hideto Kanoh

    发明人： Toshitsugu Sakaeda ,  Nobuaki Mori ,  Hideto Kanoh

    IPC分类号： C07C69/62

    CPC分类号： C12P41/005 ,  C07C67/32 ,  C07C67/343 ,  C12P7/62 ,  C07C69/65

    摘要： To provide a process for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate in high yield and efficiently. A compound (2) is reacted with a base in the presence of an aprotic solvent and then with (1E)-1,3-dichloro-1-propene in the same reaction vessel to obtain a compound (3), and then either of —COOR moieties in the compound (3) is replaced with a hydrogen atom in the same reaction vessel to obtain a compound (4): wherein R is a lower alkyl group or an aralkyl group.

    摘要翻译： 提供以高产率和高效率生产（4E）-5-氯-2-异丙基-4-戊烯酸酯的方法。 化合物（2）在非质子溶剂存在下与碱反应，然后与（1E）-1,3-二氯-1-丙烯在同一反应容器中反应，得到化合物（3），然后 化合物（3）中的-COOR部分被同一反应容器中的氢原子代替，得到化合物（4）：其中R是低级烷基或芳烷基。

    Method for producing 3-substituted 2-chloro-5-fluoro-pyridine or its salt
    5.
    发明申请
    Method for producing 3-substituted 2-chloro-5-fluoro-pyridine or its salt 失效
    制备3-取代的2-氯-5-氟 - 吡啶或其盐的方法

    公开(公告)号：US20060058529A1

    公开(公告)日：2006-03-16

    申请号：US11265179

    申请日：2005-11-03

    申请人： Yasushi Matsumura ,  Nobuaki Mori ,  Yasuhiro Yamada

    发明人： Yasushi Matsumura ,  Nobuaki Mori ,  Yasuhiro Yamada

    IPC分类号： C07D213/84 ,  C07D213/46

    CPC分类号： C07D213/80

    摘要： To provide a method for producing a 3-substituted 2-chloro-5-fluoro-pyridine or its salt in high yield from a readily available material through a short process under mild reaction conditions using a reagent which is easy for handling and simple in the reaction operation. Namely, a method for producing the following compound (2) or its salt which comprises selectively reducing a chlorine atom at the 6-position of the following compound (1) or its salt, is provided. Further, a method for producing the following compound (4) or its salt which comprises substituting a Z1 group of the following compound (2) or its salt obtained by the reduction reaction, by a Z2 group, is provided. Here, Z1 is —CO2R1, etc., and R1 is a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an aralkyl group or a cycloalkyl group. Z2 is a group different from Z1 and is —CO2R5, etc., and R5 is an alkyl group, an alkenyl group, an aryl group, an aralkyl group or a cycloalkyl group.

    摘要翻译： 提供一种通过使用容易处理的试剂在温和的反应条件下通过短时间过程从容易获得的材料以高产率制备3-取代的2-氯-5-氟 - 吡啶或其盐的方法， 反应操作。 即，提供了下述化合物（1）或其盐选择性还原6-位的氯原子的下述化合物（2）或其盐的制造方法。 此外，制备下列化合物（4）或其盐的方法，该方法包括用下列化合物（2）或其还原反应得到的盐代替Z 2 组。 这里，Z 1是-CO 2 R 1等，R 1是氢原子， 烷基，烯基，芳基，芳烷基或环烷基。 Z 2是与Z 1不同的基团，并且是-CO 2 R 5等，R 2 5是烷基，烯基，芳基，芳烷基或环烷基环

    Process for producing (4E)-5-chloro-2-isopropyl-4-pentenoate and optically active form thereof
    6.
    发明申请
    Process for producing (4E)-5-chloro-2-isopropyl-4-pentenoate and optically active form thereof 有权
    制备（4E）-5-氯-2-异丙基-4-戊烯酸酯及其光学活性形式的方法

    公开(公告)号：US20050228193A1

    公开(公告)日：2005-10-13

    申请号：US11147255

    申请日：2005-06-08

    申请人： Nobuaki Mori ,  Yasushi Matsumura ,  Yoshitomi Morizawa ,  Toshihiko Kaminuma ,  Yuuichi Aoki

    发明人： Nobuaki Mori ,  Yasushi Matsumura ,  Yoshitomi Morizawa ,  Toshihiko Kaminuma ,  Yuuichi Aoki

    IPC分类号： C07C67/32 ,  C07C67/343 ,  C07C67/48 ,  C07C69/62

    CPC分类号： C07C67/343 ,  C07B2200/07 ,  C07B2200/09 ,  C07C67/32 ,  C07C67/48 ,  C07C69/65

    摘要： The present invention provides processes for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate and an optical isomer of the (4E)-5-chloro-2-isopropyl-4-pentenoate, namely a process for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate represented by the following formula (4), which comprises reacting a compound represented by the following formula (2) in the presence of an aprotic solvent (II) with a base (II) and then with (1E)-1,3-dichloro-1-propene to give a compound represented by the following formula (3), and dealkoxycarbonylating either ester in the compound represented by the following formula (3), and a process for producing a (S)-(4E)-5-chloro-2-isopropyl-4-pentenoate represented by the following formula (5), which comprises optically resolving a (4E)-5-chloro-2-isopropyl-4-pentenoate represented by the formula (4) obtained by the above-mentioned process (wherein R is a lower alkyl group or an aralkyl group).

    摘要翻译： 本发明提供了（4E）-5-氯-2-异丙基-4-戊烯酸酯和（4E）-5-氯-2-异丙基-4-戊烯酸酯的旋光异构体的制备方法，即制备 由下式（4）表示的（4E）-5-氯-2-异丙基-4-戊烯酸酯，其包括使下式（2）表示的化合物在非质子溶剂（II）的存在下与 碱（II），然后与（1E）-1,3-二氯-1-丙烯反应，得到由下式（3）表示的化合物，和由下式（3）表示的化合物中的任一酯脱甲基羰基化，和 一种制备由下式（5）表示的（S） - （4E）-5-氯-2-异丙基-4-戊烯酸酯的方法，该方法包括光学拆分（4E）-5-氯-2-异丙基-4-戊烯酸 由上述方法（其中R是低级烷基或芳烷基）得到的式（4）表示的4-戊烯酸酯。

    Process for producing piperidinecarbinols
    7.
    发明授权
    Process for producing piperidinecarbinols 有权
    制备哌啶甲醇的方法

    公开(公告)号：US06476228B1

    公开(公告)日：2002-11-05

    申请号：US09666585

    申请日：2000-09-20

    申请人： Shu-zhong Wang ,  Takashi Okazoe ,  Yasushi Matsumura ,  Nobuaki Mori ,  Jiro Nishino ,  Kazuhiro Ookura

    发明人： Shu-zhong Wang ,  Takashi Okazoe ,  Yasushi Matsumura ,  Nobuaki Mori ,  Jiro Nishino ,  Kazuhiro Ookura

    IPC分类号： C07D21140

    CPC分类号： C07D211/22 ,  C07C255/41 ,  C07D211/78

    摘要： A process for producing a piperidinecarbinol represented by the general formula (2), which comprises reducing the trans isomer of a compound represented by the general formula (1): wherein R1 is a hydrogen atom, a lower alkyl group or an aralkyl group, R2 is a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, and X is a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, a dialkylamino group, an alkylthio group, an arylthio group or CmF2m+1— wherein m is an integer of from 1 to 20.

    摘要翻译： 一种制备由通式（2）表示的哌啶甲醇的方法，其包括降低由通式（1）表示的化合物的反式异构体：其中R1是氢原子，低级烷基或芳烷基，R2 是氢原子，低级烷基，芳基或芳烷基，X是氢原子，卤素原子，烷基，芳基，芳烷基，烷氧基，二烷基氨基， 烷硫基，芳硫基或CmF2m + 1-，其中m为1〜20的整数。

    Process for producing piperidinecarbinols
    8.
    发明授权
    Process for producing piperidinecarbinols 失效
    制备哌啶甲醇的方法

    公开(公告)号：US06197960B1

    公开(公告)日：2001-03-06

    申请号：US08835646

    申请日：1997-04-11

    申请人： Shu-zhong Wang ,  Takashi Okazoe ,  Yasushi Matsumura ,  Nobuaki Mori ,  Jiro Nishino ,  Kazuhiro Ookura

    发明人： Shu-zhong Wang ,  Takashi Okazoe ,  Yasushi Matsumura ,  Nobuaki Mori ,  Jiro Nishino ,  Kazuhiro Ookura

    IPC分类号： C07D21140

    CPC分类号： C07D211/22 ,  C07C255/41 ,  C07D211/78

    摘要： A process for producing a piperidinecarbinol represented by the general formula (2), which comprises reducing the trans isomer of a compound represented by the general formula (1): wherein R1 is a hydrogen atom, a lower alkyl group or an aralkyl group, R2 is a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, and X is a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, a dialkylamino group, an alkylthio group, an arylthio group or CmF2m+1— wherein m is an integer of from 1 to 20.

    摘要翻译： 一种制备由通式（2）表示的哌啶甲醇的方法，其包括降低由通式（1）表示的化合物的反式异构体：其中R1是氢原子，低级烷基或芳烷基，R2 是氢原子，低级烷基，芳基或芳烷基，X是氢原子，卤素原子，烷基，芳基，芳烷基，烷氧基，二烷基氨基， 烷硫基，芳硫基或CmF2m + 1-，其中m为1〜20的整数。