发明授权
US07419782B2 Methods of using a major histocompatibility complex class III haplotype to diagnose Crohn's disease
失效
使用主要组织相容性复合体III类单体型诊断克罗恩病的方法
- 专利标题： Methods of using a major histocompatibility complex class III haplotype to diagnose Crohn's disease
- 专利标题（中）： 使用主要组织相容性复合体III类单体型诊断克罗恩病的方法
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申请号： US10075425申请日： 2002-02-12
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公开(公告)号： US07419782B2公开(公告)日： 2008-09-02
- 发明人: Kent D Taylor , Jerome I Rotter , Huiying Yang
- 申请人： Kent D Taylor , Jerome I Rotter , Huiying Yang
- 申请人地址： US CA Los Angeles
- 专利权人： Cedars-Sinai Medical Center
- 当前专利权人： Cedars-Sinai Medical Center
- 当前专利权人地址： US CA Los Angeles
- 代理机构： Davis Wright Tremaine LLP
- 代理商 Seth D. Levy
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12P19/34 ; C07H21/02 ; C07H21/04
摘要：
The present invention provides a method of diagnosing or predicting susceptibility to an autoimmune disease in an individual by determining the presence or absence in the individual of a 2-2-4 haplotype at the Notch4, HSP70-HOM and D6S273 loci, where the presence of the haplotype diagnoses or predicts susceptibility to the autoimmune disease. The methods of the invention can be particularly useful for diagnosing or predicting susceptibility to Crohn's disease, rheumatoid arthritis or type I diabetes mellitus. In a preferred embodiment, a method of the invention is used to diagnose or predict susceptibility to Crohn's disease in an individual of Ashkenazi Jewish ethnicity.
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