Invention Grant
US07423044B2 Pyrimidine derivatives useful in the treatment of insulin resistance and hyperglycemia 失效
可用于治疗胰岛素抵抗和高血糖症的嘧啶衍生物

  • Patent Title: Pyrimidine derivatives useful in the treatment of insulin resistance and hyperglycemia
  • Patent Title (中): 可用于治疗胰岛素抵抗和高血糖症的嘧啶衍生物
  • Application No.: US10655471
    Application Date: 2003-09-04
  • Publication No.: US07423044B2
    Publication Date: 2008-09-09
  • Inventor: Baihua Hu
  • Applicant: Baihua Hu
  • Applicant Address: US NJ Madison
  • Assignee: Wyeth
  • Current Assignee: Wyeth
  • Current Assignee Address: US NJ Madison
  • Agency: Fish & Richardson P.C.
  • Main IPC: C07D239/34
  • IPC: C07D239/34 A61K31/505
Pyrimidine derivatives useful in the treatment of insulin resistance and hyperglycemia
Abstract:
This invention provides compounds of Formula I having the structure: wherein: B is alkyl of 1-4 carbons or alkoxy of 1-4 carbons; R1 is aryl or Het optionally substituted with R6; R2 and R3 are each independently, alkyl of 1-4 carbons, CF3, aryl or Het substituted with R6, or R2 and R3 are combined to form a cycloalkyl or heterocyclic ring optionally substituted with alkyl, benzyl, or acyl; R4, and R5 are each independently, hydrogen, halogen, alkyl of 1-4 carbons, CO2R7, SO2NHR7, CONHR7, CN, NO2 or CF3; R6 is hydrogen, halogen, NO2, alkyl of 1-4 carbons, alkoxy of 1-4 carbons, alkylcarbonyloxy of 2-7 carbon atoms, alkylcarbonyl of 2-7 carbon atoms, CF3, or COOH; and R7 is hydrogen, alkyl of 1-4 carbons, or alkylaryl where aryl group is substituted with R6; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
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