发明授权
- 专利标题: Surface-functionalized carrier material and solid phase synthesis method
- 专利标题(中): 表面官能化载体材料和固相合成方法
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申请号: US10451654申请日: 2001-12-03
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公开(公告)号: US07423117B2公开(公告)日: 2008-09-09
- 发明人: Pablo Wessig , Jürgen Bendig , Uwe Schedler
- 申请人: Pablo Wessig , Jürgen Bendig , Uwe Schedler
- 申请人地址: DE Berlin
- 专利权人: Ploy-An Gesellschaft zur Herstellung von Polymeren Fuer Spezielle Anwendungen und Analytik mbH
- 当前专利权人: Ploy-An Gesellschaft zur Herstellung von Polymeren Fuer Spezielle Anwendungen und Analytik mbH
- 当前专利权人地址: DE Berlin
- 代理机构: Kriegsman & Kriegsman
- 优先权: DE10065788 20001222
- 国际申请: PCT/EP01/14073 WO 20011203
- 国际公布: WO02/051917 WO 20020704
- 主分类号: C07K1/04
- IPC分类号: C07K1/04 ; C07K1/06 ; C07K1/10 ; C12K17/06 ; C12N11/06 ; G01N33/547
摘要:
The invention concerns a novel surface-functionalized carrier material with a polymeric surface and at least one linker compound according to the general formula (I), which is covalently bound to the surface. In the formula, P indicates the polymeric surface; R2 has the meaning OR4 or NR4R5 and R1, R4 and R5, independently of one another, indicate H, an alkyl group or an aryl group; R3 indicates H, an alkyl, an aryl, an acyl, an alkoxycarbonyl or an aryloxycarbonyl group; and the alkyl, aryl, acyl, alkoxycarbonyl and/or aryloxycarbonyl group of the radicals R1, R3, R4 and R5, independently of one another, are substituted or unsubstituted. The material according to the invention can be very easily produced by photochemical coupling and serves for the solid-phase synthesis of amino acids, peptides, proteins or molecules with at least one peptidic structural unit.
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