Invention Grant
US07427692B2 Process for preparation of 7-[α-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid
有权
制备7- [α-氨基（4-羟基苯基）乙酰氨基] -3-取代-3-头孢烯-4-羧酸的方法
![Process for preparation of 7-[α-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid](/docs/US/2008-09-23/US07427692B2/abs.jpg.600x600.jpg)
- Patent Title: Process for preparation of 7-[α-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid
- Patent Title (中): 制备7- [α-氨基（4-羟基苯基）乙酰氨基] -3-取代-3-头孢烯-4-羧酸的方法
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Application No.: US11360283Application Date: 2006-02-23
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Publication No.: US07427692B2Publication Date: 2008-09-23
- Inventor: Om Dutt Tyagi , Dnyandev Ragho Rane , Tushar Kumar Srivastava , Krishnarao Tukaram Sirsath
- Applicant: Om Dutt Tyagi , Dnyandev Ragho Rane , Tushar Kumar Srivastava , Krishnarao Tukaram Sirsath
- Applicant Address: US IN Mumbai
- Assignee: Lupin Ltd.
- Current Assignee: Lupin Ltd.
- Current Assignee Address: US IN Mumbai
- Agency: Merchant & Gould P.C.
- Priority: IN1031/MUM/2003 20031003
- Main IPC: C07C51/56
- IPC: C07C51/56
![Process for preparation of 7-[α-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid](/abs-image/US/2008/09/23/US07427692B2/abs.jpg.150x150.jpg)
Abstract:
A process for preparation of 7-[D-α-amino-α-(4-hydroxyphenyl)acetamido]-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid viz. Cefprozil of formula (I) in high purity, substantially free of impurities, which comprises preparation of mixed acid anhydride by selecting the sequence and temperature of addition of the reagents and its subsequent condensation with a protected 7-APCA; followed by hydrolysis, isolation and purification to give Cefprozil of formula (I) in the form of a monohydrate.
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