公开(公告)号：US07427692B2

公开(公告)日：2008-09-23

申请号：US11360283

申请日：2006-02-23

申请人： Om Dutt Tyagi ,  Dnyandev Ragho Rane ,  Tushar Kumar Srivastava ,  Krishnarao Tukaram Sirsath

发明人： Om Dutt Tyagi ,  Dnyandev Ragho Rane ,  Tushar Kumar Srivastava ,  Krishnarao Tukaram Sirsath

IPC分类号： C07C51/56

CPC分类号： C07D501/00 ,  C07C229/34 ,  C07F7/1804

摘要： A process for preparation of 7-[D-α-amino-α-(4-hydroxyphenyl)acetamido]-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid viz. Cefprozil of formula (I) in high purity, substantially free of impurities, which comprises preparation of mixed acid anhydride by selecting the sequence and temperature of addition of the reagents and its subsequent condensation with a protected 7-APCA; followed by hydrolysis, isolation and purification to give Cefprozil of formula (I) in the form of a monohydrate.

摘要翻译： 制备7- [D-α-氨基-α-（4-羟基苯基）乙酰氨基] -3-（1-丙烯-1-基）-3-头孢烯-4-羧酸的方法， 式（I）的头孢司列高纯度，基本上不含杂质，其包括通过选择加入试剂的顺序和温度及随后与受保护的7-APCA缩合制备混合酸酐; 然后水解，分离和纯化，得到一水合物形式的式（I）的头孢普利。

公开(公告)号：US07230097B2

公开(公告)日：2007-06-12

申请号：US10801443

申请日：2004-03-15

申请人： Om Dutt Tyagi ,  Dnyandev Ragho Rane ,  Tushar Kumar Srivastava ,  Krishnarao Tukaram Sirsath

发明人： Om Dutt Tyagi ,  Dnyandev Ragho Rane ,  Tushar Kumar Srivastava ,  Krishnarao Tukaram Sirsath

IPC分类号： C07D501/22 ,  C07D501/04

CPC分类号： C07D501/00 ,  C07C229/34 ,  C07F7/1804

摘要： A process for preparation of 7-[D-α-amino-α-(4-hydroxyphenyl)acetamido]-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid viz. Cefprozil of formula (I) in high purity, substantially free of impurities, which comprises preparation of mixed acid anhydride by selecting the sequence and temperature of addition of the reagents and its subsequent condensation with a protected 7-APCA; followed by hydrolysis, isolation and purification to give Cefprozil of formula (I) in the form of a monohydrate.

摘要翻译： 制备7- [D-α-氨基-α-（4-羟基苯基）乙酰氨基] -3-（1-丙烯-1-基）-3-头孢烯-4-羧酸的方法， 式（I）的头孢司列高纯度，基本上不含杂质，其包括通过选择加入试剂的顺序和温度及随后与受保护的7-APCA缩合制备混合酸酐; 然后进行水解，分离和纯化，得到一水合物形式的式（I）的头孢普利。