发明授权
- 专利标题： TNFα-neutralizing antibodies
- 专利标题（中）： TNFα中和抗体
-
申请号： US11090105申请日： 2005-03-24
-
公开(公告)号： US07431927B2公开(公告)日： 2008-10-07
- 发明人: Fernando Jose Rebelo Do Couto , Kristin Beth Hendricks , Stacey Ellen Wallace
- 申请人： Fernando Jose Rebelo Do Couto , Kristin Beth Hendricks , Stacey Ellen Wallace
- 申请人地址： US CA Burlingame
- 专利权人： Epitomics, Inc.
- 当前专利权人： Epitomics, Inc.
- 当前专利权人地址： US CA Burlingame
- 代理机构： Bozicevic, Field & Francis LLP
- 代理商 James S. Keddie
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/24 ; C12P21/08 ; C12N1/00 ; C12N1/16 ; C12N15/00
摘要：
The invention provides monoclonal antibodies that neutralize TNFα activity. The monoclonal antibodies may be rabbit monoclonal antibodies or monoclonal antibodies having CDR regions derived from those rabbit monoclonal antibodies. In certain embodiments, the monoclonal antibodies may be humanized. Methods of using the subject antibodies to inhibit TNFα activity, methods of treatment using those antibodies and kits containing the same are also provided. The invention finds use in a variety of research and medical applications.
公开/授权文献
- US20060216293A1 TNFalpha-neutralizing antibodies 公开/授权日：2006-09-28
信息查询
