发明授权
US07439335B2 MHC class II antigen-presenting systems and methods for activating CD4+ T cells
有权
MHC II类抗原呈递系统和激活CD4 + T细胞的方法
- 专利标题： MHC class II antigen-presenting systems and methods for activating CD4+ T cells
- 专利标题（中）： MHC II类抗原呈递系统和激活CD4 + T细胞的方法
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申请号： US10822173申请日： 2004-04-08
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公开(公告)号： US07439335B2公开(公告)日： 2008-10-21
- 发明人: Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
- 申请人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
- 申请人地址： US CA La Jolla
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 当前专利权人地址： US CA La Jolla
- 代理商 Hugh Wang; Thomas Fitting
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; C07K14/74
摘要：
The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.