Method of allowing control of a vehicle provided with at least two wheels in case of puncture of a tire, each wheel having a rim and a tire associated therewith, including the steps of inflating each tire to an operating pressure at a reference temperature; admitting a fluid compressed to a first pressure higher than the operating pressure of the tire at the reference temperature into at least one tank associated with at least one of the rims; bringing the tire into communication with the tank when the inner pressure of the tire is lower than the operating pressure by a predetermined first threshold value; measuring the inner pressure of the tire with a predetermined frequency; calculating a variation of the inner pressure in the time unit; generating an alarm signal when the variation of the inner pressure corresponds to a reduction and is higher than a predetermined value; and transmitting the alarm signal to the driver.