Device and method for needle penetrating and filling a chamber with a predetermined substance, and laser resealing a resulting needle hole in the device. A needle penetrable and laser resealable portion is pierceable with a needle to form a needle aperture therethrough to fill the chamber, and is laser resealable to hermetically seal the needle aperture by applying laser radiation. The needle penetrable and laser resealable portion defines a predetermined wall thickness in an axial direction thereof, and includes a thermoplastic that substantially prevents the formation of particles released into the chamber during penetration by and withdrawal of the needle. The thermoplastic includes a predetermined amount of pigment that allows it to substantially absorb laser radiation at the predetermined wavelength, substantially prevent the passage of radiation through the predetermined wall thickness thereof, and hermetically seal a needle aperture formed in the needle penetration region thereof in a predetermined time period.