发明授权
- 专利标题: Quinazoline analogs as receptor tyrosine kinase inhibitors
- 专利标题(中): 喹唑啉类似物作为受体酪氨酸激酶抑制剂
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申请号: US10914974申请日: 2004-08-10
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公开(公告)号: US07452895B2公开(公告)日: 2008-11-18
- 发明人: Eli Wallace , George Topalov , Joseph Lyssikatos , Alexandre Buckmelter , Qian Zhao
- 申请人: Eli Wallace , George Topalov , Joseph Lyssikatos , Alexandre Buckmelter , Qian Zhao
- 申请人地址: US CO Boulder
- 专利权人: Array BioPharma Inc.
- 当前专利权人: Array BioPharma Inc.
- 当前专利权人地址: US CO Boulder
- 代理商 John R. Moore
- 主分类号: A61K31/517
- IPC分类号: A61K31/517 ; C07D239/94
摘要:
This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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