- 专利标题: Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof
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申请号: US10515145申请日: 2003-05-26
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公开(公告)号: US07453010B2公开(公告)日: 2008-11-18
- 发明人: Philippe R. Bovy , Roberto Cecchi , Tiziano Croci , Olivier Venier
- 申请人: Philippe R. Bovy , Roberto Cecchi , Tiziano Croci , Olivier Venier
- 申请人地址: FR Paris
- 专利权人: Sanofi Aventis
- 当前专利权人: Sanofi Aventis
- 当前专利权人地址: FR Paris
- 代理商 Jianq Lin
- 优先权: FR0206561 20020529
- 国际申请: PCT/FR03/01580 WO 20030526
- 国际公布: WO03/099772 WO 20031204
- 主分类号: C07C311/00
- IPC分类号: C07C311/00 ; A61K31/18
摘要:
The invention relates to compounds of general formula (I): where R1 represents H or a (C1-C4)alkyl, —CO(C1-C4)alkyl, (C1-C4)alkylphenyl or —CO-phenyl group, said phenyl optionally being substituted; R2 represents H, a halogen atom, an —S(O)z(C1-C4)alkyl group, where z is equal to 0, 1 or 2, an —NHSO2(C1-C4)alkyl group, an —NHSO2-phenyl group or an —NHSO2—(C1-C4)alkylphenyl group, said phenyl optionally being substituted; R3 represents an —X—R4 group—in which X represents a bond, an oxygen atom or a —CH2— group and R4 represents H or a —CR5R6—COOR7 group, where R5, R6 and R7 independently represent H or a (C1-C4)alkyl group—a phenyl group optionally substituted or fused with a dioxolane group, a —CO—NR8R9 group—where R8 represents H, a (C1-C4)alkyl group or a (C1-C4)alkyl(C1-C4)alkoxy group and R9 represents a (C1-C4)alkyl(C1-C4)alkoxy group, a —(CH2)n-A group, where n is equal to 0, 1, 2, 3 or 4 and where A represents an indolyl group, a fluorenyl group or a phenyl group which is substituted, an optionally substituted —NH-phenyl group or a —CH(R10)—(CH2)n—COOR11 group, where n is 0, 1, 2 or 3 and where R11 represents H or a (C1-C4)alkyl group and R10 represents H, a (C1-C4)alkyl group or a —CH2-phenyl group, said phenyl optionally being substituted, or a —COOR12 group, where R12 represents H or a (C1-C4)alkyl group; their process of preparation and their therapeutic application.
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