发明授权
- 专利标题: Process for preparation of MR contrast agents
- 专利标题(中): 制备MR造影剂的方法
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申请号: US11002864申请日: 2004-12-02
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公开(公告)号: US07459144B2公开(公告)日: 2008-12-02
- 发明人: Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
- 申请人: Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
- 申请人地址: NO Oslo
- 专利权人: GE Healthcare AS
- 当前专利权人: GE Healthcare AS
- 当前专利权人地址: NO Oslo
- 代理商 Robert F. Chisholm
- 优先权: GB9911681.6 19990519
- 主分类号: A61B5/055
- IPC分类号: A61B5/055 ; B01J10/00
摘要:
The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
公开/授权文献
- US20050152840A1 Process 公开/授权日:2005-07-14