公开(公告)号：US10730897B2

公开(公告)日：2020-08-04

申请号：US16472579

申请日：2017-12-21

申请人： GE HEALTHCARE AS

发明人： Mikkel Jacob Thaning ,  Andreas Richard Meijer ,  Brian Christopher Bales ,  Michael James Rishel

IPC分类号： C07F13/00

摘要： The invention provides compounds suitable for use as contrast agents in magnetic resonance imaging (MRI). The compounds of the present invention are manganese (II) complexes having advantageous properties as compared with similar known compounds.

公开(公告)号：US10576169B2

公开(公告)日：2020-03-03

申请号：US15531431

申请日：2015-11-27

申请人： GE HEALTHCARE AS

发明人： Mikkel Jacob Thaning ,  Andreas Richard Meijer

IPC分类号： A61K49/10 ,  C07D257/00 ,  A61K9/00 ,  A61K31/28

摘要： The present invention relates to a method of removal of metal ion impurities, such as calcium, from lanthanide metal complexes of macrocyclic chelators. The method uses a scavenger resin to remove metal ions, displaced from chelator, by an excess of lanthanide ions. Also provided is a method of preparation of MRI contrast agents, from the purified lanthanide metal complex, by the addition of a defined excess chelator.

公开(公告)号：US09969761B2

公开(公告)日：2018-05-15

申请号：US14258247

申请日：2014-04-22

申请人： GE HEALTHCARE LIMITED ,  GE HEALTHCARE AS

发明人： Torild Wickstrom ,  Dirk-Jan In't Veld ,  Nigel John Osborn ,  Julian Grigg ,  Anthony Wilson

IPC分类号： C07H13/04 ,  C07H1/00

CPC分类号： C07H5/00 ,  C07H1/00 ,  C07H5/02 ,  C07H13/04

摘要： The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.

公开(公告)号：US09827334B2

公开(公告)日：2017-11-28

申请号：US14430148

申请日：2013-09-17

申请人： GE Healthcare AS

发明人： Mikkel Thaning ,  Andreas Olsson ,  Christian Glogard

IPC分类号： A61K49/00 ,  A61K49/04 ,  C07C231/12 ,  C07C237/46

CPC分类号： A61K49/0438 ,  C07C231/12 ,  C07C237/46

摘要： The present invention relates to a process for the preparation of Ioforminol, a contrast agent useful in X-ray imaging. More particularly, the invention relates to preparation of Ioforminol from a compound mixture comprising 1-formylamino-3,5-bis(2,3-bis(formyloxy)propan-1-ylcarbamoyl)-2,4,6-trioodobenzene by a process comprising in situ hydrolysis and a bis-alkylation.

公开(公告)号：US09815601B2

公开(公告)日：2017-11-14

申请号：US14345696

申请日：2012-09-28

申请人： GE HEALTHCARE AS

发明人： Martin Monteagle Browne

IPC分类号： B65D51/18 ,  A61J1/14 ,  B65D51/00

CPC分类号： B65D51/18 ,  A61J1/1406 ,  A61J1/1412 ,  B65D51/002 ,  B65D2101/0023

摘要： The present invention relates to a package, and more particularly to a package for sterile fluids, such as contrast media. More particularly the invention relates to a package comprising a container, a stopper (40), a cap (50) and a flip cover (60).

公开(公告)号：US20170258944A1

公开(公告)日：2017-09-14

申请号：US15531430

申请日：2015-11-27

申请人： GE HEALTHCARE AS

发明人： Mikkel Jacob Thaning ,  Andreas Richard Meijer

IPC分类号： A61K49/10

CPC分类号： A61K49/108 ,  A61K49/10 ,  A61K49/18

摘要： The present invention relates to a method of preparation of formulations of gadolinium metal complexes of the macrocyclic chelator DOTA, which further comprise a small excess of free DOTA. The method uses controlled conditions such that excess gadolinium is present as a precipitate of gadolinium oxide, with filtration to remove the excess, prior to the addition of a defined excess of DOTA chelator. Also provided is a method of preparation of MRI contrast agents based on Gd-DOTA.

公开(公告)号：US09695113B2

公开(公告)日：2017-07-04

申请号：US15100818

申请日：2014-12-08

申请人： GE Healthcare AS

发明人： Torfinn Haaland ,  Arne Askildsen ,  Rita Heskestad Kalleberg ,  Sumihar Silalahi ,  Alf Martin Farbrot ,  Inger Dagny Saanum

IPC分类号： C07C231/24 ,  C07C231/02 ,  C07C237/46

CPC分类号： C07C231/24 ,  C07C231/02 ,  C07C237/46

摘要： Alternative continuous downstream processes for the production of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”) are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially available non-ionic x-ray contrast media agents.

公开(公告)号：US20150328344A1

公开(公告)日：2015-11-19

申请号：US14809497

申请日：2015-07-27

申请人： GE Healthcare Limited ,  GE Healthcare AS

发明人： Anthony Eamon Storey ,  Clare Louise Jones ,  Denis Raymond Christophe Bouvet ,  Nicolas Lasbistes ,  Steven Michael Fairway ,  Lorenzo Williams ,  Alexander Mark Gibson ,  Robert James Nairne ,  Farhad Karimi ,  Bengt Langstrom

IPC分类号： A61K51/04 ,  B01J19/24 ,  C07D277/66

CPC分类号： A61K51/0453 ,  B01J19/24 ,  B01J2219/24 ,  C07D277/66 ,  Y02P20/55

摘要： The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.

摘要翻译： 本发明涉及制备式（I）化合物的方法：R1选自C 1-6烷基，C 2-6烯基和C 2-6炔基; 其包括：（i）与氟化物，适当的[18 F]氟化物反应，相应的式（II）化合物：其中R 2选自氢，C 1-10烷基，C 1-10卤代烷基，C 6-14芳基，C 6-14芳烷基， （CH 2 CH 2 O）q -CH 3，其中q是1至10的整数; R1如式（I）化合物所定义; R3是离去基团。 还要求具有式（II）的某些新型前体和含有这些前体的放射性药物试剂盒。

公开(公告)号：US20150191422A1

公开(公告)日：2015-07-09

申请号：US14568513

申请日：2014-12-12

申请人： GE HEALTHCARE AS

发明人： MIKKEL THANING

IPC分类号： C07C237/46 ,  A61K49/04

CPC分类号： C07C237/46 ,  A61K49/0433 ,  A61K49/0438 ,  A61K49/0452

摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CHO)—X—N(R3)—R wherein X denoted an optionally substituted alkylene group, R3 denotes a hydrogen atom or an acyl function and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties.The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.

摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地说，含碘化合物是含有通式R-N（CHO）-X-N（R3）-R的两个连接的碘化苯基的化合物，其中X表示任选取代的亚烷基，R 3表示氢原子或 酰基官能团，每个R表示进一步被亲水部分取代的三碘化苯基残基。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

公开(公告)号：US08920780B2

公开(公告)日：2014-12-30

申请号：US12665792

申请日：2008-07-04

申请人： Mikkel Thaning

发明人： Mikkel Thaning

IPC分类号： A61K49/00 ,  A61K49/04

CPC分类号： C07C237/46 ,  A61K49/0433 ,  A61K49/0438 ,  A61K49/0452

摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CHO)—X—N(R3)—R wherein X denoted an optionally substituted alkylene group, R3 denotes a hydrogen atom or an acyl function and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.

摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地说，含碘化合物是含有通式R-N（CHO）-X-N（R3）-R的两个连接的碘化苯基的化合物，其中X表示任选取代的亚烷基，R 3表示氢原子或 酰基官能团，每个R表示进一步被亲水部分取代的三碘化苯基残基。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。