发明授权
- 专利标题: HGF-SF monoclonal antibody combinations
- 专利标题(中): HGF-SF单克隆抗体组合
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申请号: US10129596申请日: 2000-11-09
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公开(公告)号: US07459536B1公开(公告)日: 2008-12-02
- 发明人: Boliang Cao , George Vande Woude
- 申请人: Boliang Cao , George Vande Woude
- 申请人地址: US DC Washington
- 专利权人: The United States of America as represented by the Secretary, Department of Health and Human Services
- 当前专利权人: The United States of America as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址: US DC Washington
- 代理机构: Ballard Spahr Andrews & Ingersoll, LLP
- 国际申请: PCT/US00/31036 WO 20001109
- 国际公布: WO01/34650 WO 20010517
- 主分类号: C07K16/00
- IPC分类号: C07K16/00
摘要:
The present invention provides a combination of anti-HGF/SF antibodies that specifically bind HGF/SF and inhibits HGF/SF activity. The present invention further provides a combination of anti-HGF/SF antibodies comprising three or more anti-HGF/SF antibodies selected from the group consisting of antibody #1 produced from hybridoma 1C10-F1-A11, antibody #4 produced from hybridoma 8H2-F2-B10, antibody #5 produced from hybridoma 13B1-E4-E10, antibody #7 produced from hybridoma 15D7-B2, and antibody #10 produced from hybridoma 31D4-C9-D4. The invention also provides a method of treating cancer in a subject comprising administering to the subject a combination of anti-HGF/SF antibodies whereby the antibodies bind to a hepatocyte growth factor, whereby the binding of the antibodies to a hepatocyte growth factor results in an inhibition of hepatocyte growth factor binding to the hepatocyte growth factor receptor, whereby the inhibition of hepatocyte growth factor binding to receptor causes an inhibition of cancer growth, thereby treating the cancer.
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