发明授权
- 专利标题： Antibody that binds zinc transporter protein 108P5H8
- 专利标题（中）： 抗体结合锌转运蛋白108P5H8
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申请号： US10024652申请日： 2001-12-17
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公开(公告)号： US07459539B2公开(公告)日： 2008-12-02
- 发明人: Pia M. Challita-Eid , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell , Elana Levin , Karen Jane Meyrick Morrison , Arthur B. Raitano , Aya Jakobovits
- 申请人： Pia M. Challita-Eid , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell , Elana Levin , Karen Jane Meyrick Morrison , Arthur B. Raitano , Aya Jakobovits
- 申请人地址： US CA Santa Monica
- 专利权人： Agensys, Inc.
- 当前专利权人： Agensys, Inc.
- 当前专利权人地址： US CA Santa Monica
- 代理机构： Morrison & Foerster LLP
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/30 ; C07K16/46
摘要：
A novel gene (designated 108P5H8) and its encoded protein, and variants thereof, are described wherein 108P5H8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 108P5H8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 108P5H8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P1E1B can be used in active or passive immunization.
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