发明授权
US07462621B2 Use of substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a] pyrimidin-5(1H)one derivatives as therapeutic agents
失效
取代的2-吡啶基-6,7,8,9-四氢嘧啶并[1,2-a]嘧啶-4-酮和7-吡啶基-2,3-二氢咪唑并[1,2-a]嘧啶-5（1H ）一种衍生物作为治疗剂
![Use of substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a] pyrimidin-5(1H)one derivatives as therapeutic agents](/docs/US/2008-12-09/US07462621B2/abs.jpg.600x600.jpg)
- 专利标题： Use of substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a] pyrimidin-5(1H)one derivatives as therapeutic agents
- 专利标题（中）： 取代的2-吡啶基-6,7,8,9-四氢嘧啶并[1,2-a]嘧啶-4-酮和7-吡啶基-2,3-二氢咪唑并[1,2-a]嘧啶-5（1H ）一种衍生物作为治疗剂
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申请号： US11696982申请日： 2007-04-05
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公开(公告)号： US07462621B2公开(公告)日： 2008-12-09
- 发明人: Thierry Gallet , Patrick Lardenois , Alistair Lochead , Severine Marguerie , Alain Nedelec , Mourad Saady , Franck Slowinski , Philippe Yaiche
- 申请人： Thierry Gallet , Patrick Lardenois , Alistair Lochead , Severine Marguerie , Alain Nedelec , Mourad Saady , Franck Slowinski , Philippe Yaiche
- 申请人地址： FR Paris JP Osaka
- 专利权人： Sanofi-Aventis,Mitsubishi Pharma Corporation
- 当前专利权人： Sanofi-Aventis,Mitsubishi Pharma Corporation
- 当前专利权人地址： FR Paris JP Osaka
- 代理商 Balaram Gupta
- 优先权： EP01402432 20010921; EP02290489 20020228
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/519 ; A61P25/28 ; A61K31/55
![Use of substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a] pyrimidin-5(1H)one derivatives as therapeutic agents](/abs-image/US/2008/12/09/US07462621B2/abs.jpg.150x150.jpg)
摘要：
The invention relates to an use of pyrimidone derivative represented by formula (I) or a salt thereof: wherein m, n, p, X, Y, R1, R2, R3, R4 and R5 are as defined herein for treating a variety of disease states. More specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β or GSK3β and cdk5/p25, such as Alzheimer's disease.
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