发明授权
US07465719B2 Carbamic acid compounds comprising an ester or ketone linkage as HDAC inhibitors
失效
包含酯或酮键的氨基甲酸化合物作为HDAC抑制剂
- 专利标题: Carbamic acid compounds comprising an ester or ketone linkage as HDAC inhibitors
- 专利标题(中): 包含酯或酮键的氨基甲酸化合物作为HDAC抑制剂
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申请号: US10542281申请日: 2004-01-19
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公开(公告)号: US07465719B2公开(公告)日: 2008-12-16
- 发明人: Paul W. Finn , Ivars Kalvinsh , Einars Loza , Aleksandrs Gutcaits , Irena Olutnika , Ludmila Serpionova , Vija Gailite , Rasma Bokaldere
- 申请人: Paul W. Finn , Ivars Kalvinsh , Einars Loza , Aleksandrs Gutcaits , Irena Olutnika , Ludmila Serpionova , Vija Gailite , Rasma Bokaldere
- 申请人地址: GB Abingdon
- 专利权人: Topotarget UK Limited
- 当前专利权人: Topotarget UK Limited
- 当前专利权人地址: GB Abingdon
- 代理机构: Nixon & Vanderhye P.C.
- 国际申请: PCT/GB2004/000147 WO 20040119
- 国际公布: WO2004/065354 WO 20040805
- 主分类号: A61K31/55
- IPC分类号: A61K31/55 ; A61K31/445
摘要:
This invention pertains to certain carbamic acid compounds of the formula (I), which inhibit HDAC (histone deacetylase) activity: wherein: J is a linking functional group and is independently:—O —C(═O)— or —C(═O)—O — or —C(═O)—; Cy is a cyclyl group and is independently: C3-20carbocyclyl, C3-20heterocyclyl, or C5-20aryl; and is optionally substituted; Q1 is a cyclyl leader group, and is independently a divalent bidentate group obtained by removing two hydrogen atoms from a ring carbon atom of a saturated monocyclic hydrocarbon having from 4 to 7 ring atoms, or by removing two hydrogen atoms from a ring carbon atom of saturated monocyclic heterocyclic compound having from 4 to 7 ring atoms including 1 nitrogen ring atom or 1 oxygen ring atom; and is optionally substituted; Q2 is an acid leader group, and is independently: C1-8alkylene; and is optionally substituted; or: Q2 is an acid leader group, and is independently: C5-20arylene; C5-20arylene-C1-7alkylene; C1-7alkylene-C5-20arylene; or C1-7alkylene-C5-20aryleneC1-7alkylene; and is optionally substituted; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC,and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.
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