发明授权
- 专利标题: Biphenyl vasopressin agonists
- 专利标题(中): 联苯加压素激动剂
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申请号: US11502982申请日: 2006-08-11
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公开(公告)号: US07465722B2公开(公告)日: 2008-12-16
- 发明人: Amedeo A. Failli , John P. Dusza , Thomas J. Caggiano , Jay S. Shumsky , Kevin A. Memoli , Eugene J. Trybulski
- 申请人: Amedeo A. Failli , John P. Dusza , Thomas J. Caggiano , Jay S. Shumsky , Kevin A. Memoli , Eugene J. Trybulski
- 申请人地址: US NJ Madison
- 专利权人: Wyeth
- 当前专利权人: Wyeth
- 当前专利权人地址: US NJ Madison
- 代理机构: Pepper Hamilton LLP
- 主分类号: C07D487/02
- IPC分类号: C07D487/02 ; A61K31/551
摘要:
A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1-C6) lower alkyl, and n is 1; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or(2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen or (C1-C6) lower alkoxy; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or(2) a 5-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, (C1-C6) lower alkoxy, or halogen; or(3) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen, or (C1-C6) lower alkoxy; represents a 5-membered aromatic (unsaturated) heterocyclic ring having one sulfur atom, optionally substituted by (C1-C6) lower alkyl, halogen, or (C1-C6) lower alkoxy; R1 is a moiety of the formula and R2, R3, R7, R8 and R9 are, independently, selected from a group consisting of hydrogen, (C1-C3) lower alkyl, OCH3, halogen, CF3, —SCH3, OCF3, SCF3, or CN; or a pharmaceutically acceptable salt, or pro-drug form thereof.
公开/授权文献
- US20060276456A1 Biphenyl vasopressin agonists 公开/授权日:2006-12-07
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