发明授权
US07470663B2 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
有权
包含聚亚烷基二醇的胰岛素药物 - 低聚物缀合物的混合物，其用途及其制备方法
- 专利标题： Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
- 专利标题（中）： 包含聚亚烷基二醇的胰岛素药物 - 低聚物缀合物的混合物，其用途及其制备方法
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申请号： US11417586申请日： 2006-05-04
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公开(公告)号： US07470663B2公开(公告)日： 2008-12-30
- 发明人: Nnochiri N. Ekwuribe , Christopher H. Price , Aslam M. Ansari , Balasingam Radhakrishnan , Amy L. Odenbaugh
- 申请人： Nnochiri N. Ekwuribe , Christopher H. Price , Aslam M. Ansari , Balasingam Radhakrishnan , Amy L. Odenbaugh
- 申请人地址： IN
- 专利权人： Biocon Limited
- 当前专利权人： Biocon Limited
- 当前专利权人地址： IN
- 代理机构： Moore & Van Allen PLLC
- 代理商 Marianne Fuierer
- 主分类号： A61K38/28
- IPC分类号： A61K38/28 ; C07K14/62
摘要：
A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may also be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may also result in less inter-subject variability than polydispersed mixtures of similar conjugates.
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