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25 条记录 (耗时 0.039 秒)

    Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
    6.
    发明授权
    Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 失效
    包含聚亚烷基二醇的生长激素药物 - 低聚物缀合物的混合物及其制备方法及其制备方法

    公开(公告)号：US06828305B2

    公开(公告)日：2004-12-07

    申请号：US09873757

    申请日：2001-06-04

    申请人： Nnochiri N. Ekwuribe ,  Christopher H. Price ,  Aslam M. Ansari ,  Amy L. Odenbaugh

    发明人： Nnochiri N. Ekwuribe ,  Christopher H. Price ,  Aslam M. Ansari ,  Amy L. Odenbaugh

    IPC分类号： A61K3827

    CPC分类号： C07K14/61 ,  A61K38/27 ,  A61K47/60

    摘要： Mixtures of conjugates in which each conjugate in the mixture comprises a growth hormone drug coupled to an oligomer that includes a polyalkylene glycol moiety wherein the mixtures have a molecular weight distribution with a standard deviation of less than about 22 Daltons are disclosed. Methods of treating growth hormone deficiency in a subject in need of such treatment and methods of accelerating the growth rate of an animal arc also disclosed. Processes for synthesizing substantially monodispersed mixtures of conjugates wherein each conjugate comprises a growth hormone drug coupled to an oligomer that comprises a polyethylene glycol moiety are further provided.

    摘要翻译： 缀合物的混合物，其中混合物中的每个缀合物包含与包含聚亚烷基二醇部分的低聚物偶联的生长激素药物，其中所述混合物具有小于约22道尔顿的标准偏差的分子量分布。 还公开了在需要这种治疗的受试者中治疗生长激素缺乏的方法和加速动物弧的生长速率的方法。 用于合成基本上单分散的缀合物混合物的方法，其中每个缀合物包含与包含聚乙二醇部分的低聚物偶联的生长激素药物。

    Methods for delivery therapeutic compounds across the blood-brain barrier
    8.
    发明授权
    Methods for delivery therapeutic compounds across the blood-brain barrier 失效
    递送治疗化合物穿过血脑屏障的方法

    公开(公告)号：US06703381B1

    公开(公告)日：2004-03-09

    申请号：US09134803

    申请日：1998-08-14

    申请人： Nnochiri N. Ekwuribe ,  Balasingam Rhadakrishnan ,  Christopher H. Price ,  Wes Anderson, Jr. ,  Aslam M. Ansari

    发明人： Nnochiri N. Ekwuribe ,  Balasingam Rhadakrishnan ,  Christopher H. Price ,  Wes Anderson, Jr. ,  Aslam M. Ansari

    IPC分类号： A61K3156

    CPC分类号： A61K47/60

    摘要： The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugates comprise a therapeutic compound conjugated to an oligomer, wherein the oligomer comprises a lipophilic moiety coupled to a hydrophilic moiety. The conjugates of the invention further comprise therapeutic agents such as proteins, peptides, nucleosides, nucleotides, antiviral agents, antineoplastic agents, antibiotics, etc., and prodrugs, precursors, derivatives and intermediates thereof, chemically coupled to amphiphilic oligomers.

    摘要翻译： 本发明涉及能够穿过血脑屏障（“BBB”）的两亲药物 - 低聚物缀合物以及制备和使用这种缀合物的方法。 两亲药物 - 低聚物缀合物包含与低聚物缀合的治疗化合物，其中所述寡聚物包含与亲水部分偶联的亲脂性部分。 本发明的缀合物还包含治疗剂，例如蛋白质，肽，核苷，核苷酸，抗病毒剂，抗肿瘤剂，抗生素等，以及与两亲寡聚物化学偶联的前药，前体，衍生物和中间体。

    Methods for the extraction of phytochemicals from fibrous plants in the absence of solvent
    9.
    发明授权
    Methods for the extraction of phytochemicals from fibrous plants in the absence of solvent 失效
    在没有溶剂的情况下从纤维植物中提取植物化学物质的方法

    公开(公告)号：US5756098A

    公开(公告)日：1998-05-26

    申请号：US571231

    申请日：1995-12-12

    申请人： Christopher H. Price ,  Dale Hedtke ,  Geoffrey N. Richards ,  Michael S. Tempesta

    发明人： Christopher H. Price ,  Dale Hedtke ,  Geoffrey N. Richards ,  Michael S. Tempesta

    IPC分类号： C08B37/14 ,  C07D311/40 ,  C08B37/00 ,  D21C1/10 ,  D21C5/00 ,  A01N65/00 ,  A61K35/78 ,  B30B13/00 ,  C07G1/00

    CPC分类号： D21C1/10 ,  C07D311/40 ,  C08B37/0036 ,  C08B37/006 ,  D21C5/00

    摘要： Methods and apparatus are provided for the recovery of organic compounds from fibrous plant materials. Organic compounds which can be recovered from the fibrous plant materials include plant metabolites, such as arabinogalactan and phenols, which can be isolated from the wood, for example, of the Western Larch and Tamarack tree varieties. In addition to the recovery of organic compounds from wood, fibrous wood products also may be isolated, in the form of a clean fiber that can be used, for example, as raw material in wood processing applications or in the manufacture of high quality paper products. In one embodiment, a fibrous plant material first is compressed, to recover a liquid exudate and a first pressed plant fiber product. Optionally, the fibrous plant material, such as wood particles, is compressed in the substantial absence of any added solvent, to produce a pure normal liquid exudate and a first pressed plant product. The first plant fiber product then may be impregnated with, for example, an aqueous solvent, to recover an extract liquor and impregnated plant fiber. The impregnated plant fiber then is compressed to recover a liquid pressate and a second pressed fiber product. Using these methods, in one embodiment, a substantially pure arabinogalactan exudate and a wood fiber product can be recovered from wood of the genus Larix, with minimal coextraction of phenols. Additionally, a variety of different plant metabolites may be isolated and/or identified from different kinds of woody plants using the methods and apparatus.

    摘要翻译： 提供了从纤维植物材料回收有机化合物的方法和装置。 可以从纤维性植物材料回收的有机化合物包括植物代谢物，例如阿拉伯半乳聚糖和酚，其可以从木材例如西部落叶松和Tamarack树品种分离。 除了从木材中回收有机化合物之外，纤维木制品也可以分离成干净纤维的形式，例如可以用作木材加工应用中的原料或用于制造高品质纸制品 。 在一个实施方案中，首先将纤维状植物材料压缩，以回收液体渗出物和第一受压植物纤维产品。 任选地，基本上没有任何添加的溶剂，纤维状植物材料如木颗粒被压缩，以产生纯正常液体渗出物和第一压制植物产品。 然后可以用例如水性溶剂浸渍第一植物纤维产品，以回收提取液和浸渍的植物纤维。 然后将浸渍的植物纤维压缩以回收液体压制物和第二压制纤维产品。 使用这些方法，在一个实施方案中，基本上纯的阿拉伯半乳聚糖渗出物和木纤维产物可以通过酚的最小共萃取从落叶松的木材中回收。 另外，各种不同的植物代谢物可以使用方法和装置从不同种类的木本植物中分离和/或鉴定。