发明授权
- 专利标题: Phthalazinone derivatives
- 专利标题(中): 酞嗪衍生物
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申请号: US11550004申请日: 2006-10-17
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公开(公告)号: US07470688B2公开(公告)日: 2008-12-30
- 发明人: Muhammad Hashim Javaid , Keith Allan Menear , Sylvie Gomez , Marc Geoffrey Hummersone , Niall Morrison Barr Martin , Graeme Cameron Murray Smith , Xiao-Ling Fan Cockcroft , Frank Kerrigan
- 申请人: Muhammad Hashim Javaid , Keith Allan Menear , Sylvie Gomez , Marc Geoffrey Hummersone , Niall Morrison Barr Martin , Graeme Cameron Murray Smith , Xiao-Ling Fan Cockcroft , Frank Kerrigan
- 申请人地址: GB Cornwall
- 专利权人: Maybridge Limited
- 当前专利权人: Maybridge Limited
- 当前专利权人地址: GB Cornwall
- 代理机构: Michael Best & Friedrich LLP
- 优先权: GB0521373.1 20051020
- 主分类号: A61K31/502
- IPC分类号: A61K31/502 ; A61K31/5355 ; A61K31/53 ; C07D487/00 ; C07D413/10 ; C07D253/04 ; C07D253/06 ; C07D251/10 ; A61P9/10
摘要:
A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; D is selected from: (i) where Y1 is selected from CH and N, Y2 is selected from CH and N, Y3 is selected from CH, CF and N; and (ii) where Q is O or S; RD is: wherein RN1 is selected from H and optionally substituted C1-10 alkyl; X is selected from a single bond, NRN2, CRC3RC4 and C═O; RN2 is selected from H and optionally substituted C1-10 alkyl; RC3 and RC4 are independently selected from H, R, C(═O)OR, where R is optionally substituted C1-10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; Y is selected from NRN3 and CRC1RC2; RC1 and RC2 are independently selected from H, R, C(═O)OR, where R is optionally substituted C1-10 alkyl, optionally substituted C5-20 aryl or optionally substituted C3-20 heterocyclyl; RC1 and RC2 together with the carbon atom to which they are attached may form an optionally substituted spiro-fused C5-7 carbocylic or heterocyclic ring; and when X is a single bond RN1 and RC2 may together with the N and C atoms to which they are bound, form an optionally substituted C5-7 heterocyclic ring; and when X is CRC3RC4, RC2 and RC4 may together form an additional bond, such that there is a double bond between the atoms substituted by RC1 and RC3.
公开/授权文献
- US20070093489A1 PHTHALAZINONE DERIVATIVES 公开/授权日:2007-04-26
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