发明授权
- 专利标题: Thrombin compositions
- 专利标题(中): 凝血酶组合物
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申请号: US11539276申请日: 2006-10-06
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公开(公告)号: US07473543B2公开(公告)日: 2009-01-06
- 发明人: Shan Jiang , Richard I. Senderoff , Jeffrey D. Meyer
- 申请人: Shan Jiang , Richard I. Senderoff , Jeffrey D. Meyer
- 申请人地址: US WA Seattle
- 专利权人: ZymoGenetics, Inc.
- 当前专利权人: ZymoGenetics, Inc.
- 当前专利权人地址: US WA Seattle
- 代理商 Jennifer K. Johnson
- 主分类号: C12N9/74
- IPC分类号: C12N9/74
摘要:
Compositions comprising thrombin and methods of preparing them are disclosed. The composition may be in the form of an aqueous solution at pH 5.7-7.4 consisting essentially of 0.1 mg/mL to 5.0 mg/mL thrombin, 2% to 4% (w/v) sucrose, 3.5% to 5% (w/v) mannitol, 50 mM to 300 mM NaCl, 0-5 mM CaCl2, 0.03% to 1% (w/v) of a surfactant or high-molecular-weight polyethylene glycol, and a physiologically acceptable buffer, or may be in lyophilized form.
公开/授权文献
- US20070104705A1 THROMBIN COMPOSITIONS 公开/授权日:2007-05-10