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公开(公告)号：US11518988B2
公开(公告)日：2022-12-06
申请号：US16971491
申请日：2019-02-22
摘要： The present invention relates to polypeptide variants of porcine trypsin, to nucleic acid molecules encoding these variants, and to host cells comprising such nucleic acid molecules. It also relates to the use of these variants in methods for producing insulin. The invention further relates to the use of these variants as medicaments, as food ingredients, or as feed ingredients and to the use of these variants within a process of manufacturing a food ingredient or a feed ingredient.
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公开(公告)号：US11085031B2
公开(公告)日：2021-08-10
申请号：US16097485
申请日：2017-04-28
IPC分类号： C12N9/74 , A61K9/00 , C07K14/745 , C12N15/62 , A61P7/02 , A61K38/36 , A61K38/48 , A61K45/06 , A61K38/00
摘要： Compositions and methods for regulating the blood coagulation pathway are disclosed. More particularly, the present disclosure relates to thrombin-thrombomodulin fusion proteins and their use as blood anticoagulants and for treating sepsis.
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公开(公告)号：US10900027B2
公开(公告)日：2021-01-26
申请号：US15766901
申请日：2016-10-07
发明人： Michael Kalafatis , Joseph Wiencek
摘要： During the process of coagulation, prothrombin is activated to α-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for modulation of the activation of prothrombin. In certain embodiments, a recombinant prothrombin with at least one point mutation or deletion is provided.
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公开(公告)号：US20200206325A1
公开(公告)日：2020-07-02
申请号：US16812592
申请日：2020-03-09
申请人： ARTHREX, INC.
摘要： A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.
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公开(公告)号：US20200032239A1
公开(公告)日：2020-01-30
申请号：US16595999
申请日：2019-10-08
发明人： Roberto Meidler , Oleg Belyaev , Liliana Bar , Israel Nur
摘要： Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
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公开(公告)号：US10538754B2
公开(公告)日：2020-01-21
申请号：US15547839
申请日：2015-02-06
发明人： Lior Weissman , Dana Sella , Israel Nur , Caixia Jiang , Baochang An
摘要： The present invention is directed to methods for the production of thrombin from a source of prothrombin using a given BaSO4 reagent as an adsorbent of prothrombin as well as methods for evaluating the suitability of a given BaSO4 reagent for use in preparation of thrombin. In at least one embodiment, the method includes contacting a sample of the given BaSO4 reagent with a source of prothrombin to obtain BaSO4-adsorbed prothrombin, and subsequently evaluating the pro-coagulant activity of the BaSO4-adsorbed prothrombin. In another embodiment, the method includes the step of evaluating relative to the pro-coagulant activity of normal mammalian plasma.
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公开(公告)号：US10159719B2
公开(公告)日：2018-12-25
申请号：US14830984
申请日：2015-08-20
发明人： Yair Pilpel , Sivan Doron , Yuri Zherdev , Tamara Byk-Tennenbaum
IPC分类号： A01N1/00 , A61K38/48 , A61K47/26 , A61M5/19 , C12N15/113 , G01N33/53 , C12N9/74 , C12N15/115
摘要： The present invention is directed to compounds, methods for stabilizing thrombin activity with a thrombin binding oligonucleotide and to stabilized thrombin. The thrombin binding oligonucleotide is capable of inhibiting thrombin activity whereby the inhibition can be reversed with an antisense oligonucleotide.
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公开(公告)号：US10131896B2
公开(公告)日：2018-11-20
申请号：US14519552
申请日：2014-10-21
发明人： Nadav Orr , Yair Pilpel , Sivan Doron
摘要： The present invention is directed to compounds useful in stabilizing thrombin activity, thrombin compositions comprising the compounds, methods of using the compounds and methods of identifying compounds capable of stabilizing thrombin activity. The compounds are preferably isolated peptides comprising or interacting with the gamma loop of thrombin.
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公开(公告)号：US09932388B2
公开(公告)日：2018-04-03
申请号：US14883574
申请日：2015-10-14
发明人： Ashok Kumar Nuvula , Mitali Samaddar , Neelima Vadde , Zinia Chakraborty , Swapna Sagar Duggineni , Uma Devi Komath
CPC分类号： C07K14/75 , A61L24/02 , A61L24/106 , A61L24/108 , C12N9/6429 , C12Y304/21005
摘要： The present invention relates to a chromatographic process for obtaining purified fibrinogen and thrombin from human plasma. The purified fibrinogen and thrombin preparations contain plasminogen in amounts less than 1 ug/mL. The low levels of plasminogen eliminates use of a proteolytic inhibitor, such as aprotinin in fibrin sealant kits which are used for human therapeutic applications.
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公开(公告)号：US20170258877A1
公开(公告)日：2017-09-14
申请号：US15455417
申请日：2017-03-10
申请人： ARTHREX, INC.
CPC分类号： A61K38/4833 , B01L3/5021 , B01L3/50825 , B01L2200/026 , B01L2300/041 , B01L2300/042 , B01L2300/047 , B01L2300/0609 , B01L2300/0681 , B01L2300/0832 , B01L2300/16 , C12N9/6429 , C12Y304/21005
摘要： A system for preparing a thrombin serum includes a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port.
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