发明授权
- 专利标题： Artificial human chromosome containing human antibody a light chain gene
- 专利标题（中）： 含有人抗体的人造人染色体为轻链基因
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申请号： US10477471申请日： 2002-05-10
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公开(公告)号： US07476536B2公开(公告)日： 2009-01-13
- 发明人: Yoshimi Kuroiwa , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
- 申请人： Yoshimi Kuroiwa , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
- 申请人地址： JP Tokyo
- 专利权人： Kirin Pharma Kabushiki Kaisha
- 当前专利权人： Kirin Pharma Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo
- 代理机构： Foley & Lardner LLP
- 代理商 Stephen A. Bent
- 优先权： JP2001-142371 20010511
- 国际申请： PCT/JP02/04587 WO 20020510
- 国际公布： WO02/092812 WO 20021121
- 主分类号： C12N15/63
- IPC分类号： C12N15/63 ; C12N21/02 ; C12N15/00
摘要：
The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the non-human animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
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