发明授权
US07476741B2 Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
失效
取代的4H-色素，2H-色烯，着色剂和类似物作为胱天蛋白酶的活化剂和凋亡诱导剂及其用途
- 专利标题： Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
- 专利标题（中）： 取代的4H-色素，2H-色烯，着色剂和类似物作为胱天蛋白酶的活化剂和凋亡诱导剂及其用途
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申请号： US10514426申请日： 2003-05-16
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公开(公告)号： US07476741B2公开(公告)日： 2009-01-13
- 发明人: Sui Xiong Cai , Songchun Jiang , Giorgio Attardo , Réal Denis , Richard Storer , Rabindra Rej
- 申请人： Sui Xiong Cai , Songchun Jiang , Giorgio Attardo , Réal Denis , Richard Storer , Rabindra Rej
- 申请人地址： US CA San Diego CA Quebec
- 专利权人： Cytovia, Inc.,Shire BioChem, Inc.
- 当前专利权人： Cytovia, Inc.,Shire BioChem, Inc.
- 当前专利权人地址： US CA San Diego CA Quebec
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 国际申请： PCT/US03/15432 WO 20030516
- 国际公布： WO03/096982 WO 20031127
- 主分类号： C07D405/00
- IPC分类号： C07D405/00
摘要：
The present invention is directed to substituted 4H-chromenes, 2H-chromenes, chromans and analogs thereof, represented by the general Formula (I) wherein R5, A, B, X, Y, Z and dotted lines are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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