发明授权
- 专利标题： Beta-secretase substrates and uses thereof
- 专利标题（中）： β-分泌酶底物及其用途
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申请号： US11523507申请日： 2006-09-19
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公开(公告)号： US07479372B2公开(公告)日： 2009-01-20
- 发明人: Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
- 申请人： Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
- 申请人地址： US NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 Joan E. Switzer; William Krovatin
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
公开/授权文献
- US20070184488A1 Beta-secretase substrates and uses thereof 公开/授权日：2007-08-09
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