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公开(公告)号:US07479372B2
公开(公告)日:2009-01-20
申请号:US11523507
申请日:2006-09-19
申请人: Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
发明人: Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
IPC分类号: G01N33/53
CPC分类号: C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要: The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
摘要翻译: 本发明提供用于测量β-分泌酶活性的各种测定中的合成β-分泌酶肽底物。 公开了在各种测定中识别合成底物和抗体应用的抗体。 本文所公开的肽底物的水解速度明显快于从其中衍生出底物序列的瑞典突变体APP。
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公开(公告)号:US07132401B2
公开(公告)日:2006-11-07
申请号:US10480954
申请日:2002-05-17
申请人: Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
发明人: Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
IPC分类号: A61K38/08
CPC分类号: C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要: The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
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公开(公告)号:US20070184488A1
公开(公告)日:2007-08-09
申请号:US11523507
申请日:2006-09-19
申请人: Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
发明人: Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
CPC分类号: C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要: The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
摘要翻译: 本发明提供用于测量β-分泌酶活性的各种测定中的合成β-分泌酶肽底物。 公开了在各种测定中识别合成底物和抗体应用的抗体。 本文所公开的肽底物的水解速度明显快于从其中衍生出底物序列的瑞典突变体APP。
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公开(公告)号:US20050032190A1
公开(公告)日:2005-02-10
申请号:US10480954
申请日:2002-05-17
申请人: Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
发明人: Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
IPC分类号: A61K38/00 , C07K5/107 , C07K5/11 , C07K5/113 , C07K7/06 , C07K14/47 , C07K16/18 , C12P21/06 , C12P21/08 , C12Q1/37 , G01N33/68 , C12N9/64 , C07K16/40 , G01N33/53 , G01N33/567
CPC分类号: C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要: The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
摘要翻译: 本发明提供用于测量β-分泌酶活性的各种测定中的合成β-分泌酶肽底物。 公开了在各种测定中识别合成底物和抗体应用的抗体。 本文所公开的肽底物的水解速度明显快于从其中衍生出底物序列的瑞典突变体APP。
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