发明授权
- 专利标题： Reshaped human antibody to human interleukin-6 receptor
- 专利标题（中）： 重组人抗人白细胞介素-6受体
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申请号： US10837904申请日： 2004-05-04
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公开(公告)号： US07479543B2公开(公告)日： 2009-01-20
- 发明人: Masayuki Tsuchiya , Koh Sato , Mary Margaret Bendig , Steven Tarran Jones , Jose William Saldanha
- 申请人： Masayuki Tsuchiya , Koh Sato , Mary Margaret Bendig , Steven Tarran Jones , Jose William Saldanha
- 申请人地址： JP Tokyo
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo
- 代理机构： Foley & Lardner LLP
- 优先权： JP3-95476 19910425; JP4-32084 19920219
- 主分类号： C07K16/00
- IPC分类号： C07K16/00
摘要：
A reshaped human antibody to the human IL-6R, comprising: (A) an L chain comprising, (1) a human L chain C region, and (2) an L chain V region comprising human L chain framework regions (FRs), and mouse L chain complementary determination regions (CDRs) of a momoclonal antibody to the IL-6 receptor (IL-6R); and (B) an H chain comprising, (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRS, and mouse H chain CDRs of a monoclonal antibody to the IL-6R. Since major portion of the reshaped human antibody is derived from a human antibody and the mouse CDRs which are less immunogenic, the present reshaped human antibody is less immunogenic to human, and therefor is promised for therapeutic uses.
公开/授权文献
- US20050142635A1 Reshaped human antibody to human interleukin-6 receptor 公开/授权日：2005-06-30