Spatially dependent colorant interaction effects are identified and isolated from other aspects of spatially dependent colorant appearance nonuniformities. A decorrelating function for compensating for the identified spatially dependent colorant interaction effects is determined. Spatially dependent single colorant compensating functions for compensating for the other aspects of the spatially dependent colorant appearance nonuniformities may also be determined. Image data is processed through the decorrelating function, thereby generating colorant values that are compensated for spatially dependent colorant interaction effects. Optionally, image data is also processed through the spatially dependent single colorant compensating functions, thereby generating colorant values that are compensated for both aspects of colorant appearance nonuniformities. The two kinds of compensating functions may be determined, calibrated and/or stored at different spatial and temporal frequencies or resolutions. One or both of the compensating functions may be employed to maintain consistency across a plurality of rendering devices (e.g., marking engines).