发明授权
- 专利标题： Multimerization of HIV-1 Vif protein as a therapeutic target
- 专利标题（中）： HIV-1 Vif蛋白多聚化作为治疗靶点
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申请号： US11809953申请日： 2007-06-04
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公开(公告)号： US07498138B2公开(公告)日： 2009-03-03
- 发明人: Hui Zhang , Roger J. Pomerantz , Bin Yang
- 申请人： Hui Zhang , Roger J. Pomerantz , Bin Yang
- 申请人地址： US PA Philadelphia
- 专利权人： Thomas Jefferson University
- 当前专利权人： Thomas Jefferson University
- 当前专利权人地址： US PA Philadelphia
- 代理机构： Drinker Biddle & Reath LLP
- 代理商 Daniel A. Monaco
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
The HIV-1 protein Vif comprises a multimerization domain that allows Vif-Vif interaction and Vif multimerization, which is important for Vif function in the HIV-1 life-cycle. A method for screening for an antagonist of Vif comprises contacting the multimerization domain of Vif with a test compound that specifically binds the multimerization domain. Antagonists identified by the screening assay inhibit Vif multimerization. The antagonists inhibit essential functions of Vif and accordingly are useful as inhibitors of HIV-1 replication.
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