An optical sensing system and method is disclosed. In one embodiment, a method of detecting a scattering center includes the step of providing an optical sensing system including a light source, one or more bus waveguides where a first bus waveguide has an input port that is in optical communication with the light source, a microresonator optically coupled to the one or more bus waveguides, and a scattering center which is capable of optically coupling to the microresonator. The method further includes the steps of exciting at least a first resonant guided optical mode of the microresonator with the light source, altering a strength of optical coupling between the scattering center and the microresonator to induce a change in optical scattering between the first mode and at least a second guided optical mode of the microresonator, and detecting a change in transfer of energy from the first mode to the second mode.