发明授权
US07514426B2 Substituted imidazol[1,5-A][1,2,4]triazolo[1,5-D][1,4]benzodiazepine derivatives
有权
取代的咪唑[1,5-A] [1,2,4]三唑并[1,5-D] [1,4]苯并二氮杂衍生物
![Substituted imidazol[1,5-A][1,2,4]triazolo[1,5-D][1,4]benzodiazepine derivatives](/docs/US/2009-04-07/US07514426B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted imidazol[1,5-A][1,2,4]triazolo[1,5-D][1,4]benzodiazepine derivatives
- 专利标题（中）： 取代的咪唑[1,5-A] [1,2,4]三唑并[1,5-D] [1,4]苯并二氮杂衍生物
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申请号： US11252025申请日： 2005-10-17
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公开(公告)号： US07514426B2公开(公告)日： 2009-04-07
- 发明人: Henner Knust , Andrew William Thomas
- 申请人： Henner Knust , Andrew William Thomas
- 申请人地址： US NJ Nutley
- 专利权人： Hoffman-La Roche Inc.
- 当前专利权人： Hoffman-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权： EP04105169 20041020
- 主分类号： A61P25/28
- IPC分类号： A61P25/28 ; A61K31/55 ; C07D243/00
![Substituted imidazol[1,5-A][1,2,4]triazolo[1,5-D][1,4]benzodiazepine derivatives](/abs-image/US/2009/04/07/US07514426B2/abs.jpg.150x150.jpg)
摘要：
The present invention is concerned with substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives of formula I wherein R1 is hydrogen, halogen, lower alkyl, lower alkynyl, cycloalkyl, heterocycloalkyl, benzyl, cyano, lower alkoxy, OCF3, —NHR, —NHC(O)R or —NHSO2R; R2 is lower alkyl substituted by halogen; R3 is hydrogen, methyl or aryl; R is lower alkyl, cycloalkyl or aryl; and pharmaceutically acceptable acid addition salts thereof.