Invention Grant
US07517542B2 Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease
有权
二亚戊基二萜类化合物，以及包含提取物的组合物，其中包括从其中分离出来的托雷单抗或二萜二萜化合物或萜类化合物，用于预防和治疗心血管疾病
- Patent Title: Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease
- Patent Title (中): 二亚戊基二萜类化合物，以及包含提取物的组合物，其中包括从其中分离出来的托雷单抗或二萜二萜化合物或萜类化合物，用于预防和治疗心血管疾病
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Application No.: US10591282Application Date: 2005-02-22
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Publication No.: US07517542B2Publication Date: 2009-04-14
- Inventor: Tae-Sook Jeong , Woo-Song Lee , Hyoung-Chin Kim , Yang-Kyu Choi , Ju-Ryoung Kim , So-Jin An , Kyoung-Ran Im , Ki-Chang Jang , Og-Sung Moon , Jun-Seock Son
- Applicant: Tae-Sook Jeong , Woo-Song Lee , Hyoung-Chin Kim , Yang-Kyu Choi , Ju-Ryoung Kim , So-Jin An , Kyoung-Ran Im , Ki-Chang Jang , Og-Sung Moon , Jun-Seock Son
- Applicant Address: KR Taijeon-Si
- Assignee: Korea Research Institute of Bioscience
- Current Assignee: Korea Research Institute of Bioscience
- Current Assignee Address: KR Taijeon-Si
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2004-0014236 20040303; KR10-2004-0089372 20041104; KR10-2004-0112140 20041224
- International Application: PCT/KR2005/000472 WO 20050222
- International Announcement: WO2005/084141 WO 20050915
- Main IPC: A01N65/00
- IPC: A01N65/00
Abstract:
The present invention relates to a composition for the prevention and the treatment of cardiovascular disease containing extracts of T. nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient.T. nucifera extracts or abietane diterpenoid compound or terpenoid compound isolated from the same of the present invention not only shows excellent anti-oxidative activity to LDL but also effectively inhibits ACAT activity. Further, T. nucifera extracts of the present invention reduce blood LDL cholesterol and total cholesterol.Therefore, the composition of the present invention can be effectively used for the prevention and the treatment of cardiovascular diseases including hyperlipidemia and atherosclerosis caused by the LDL oxidation and the synthesis and accumulation of cholesteryl ester.
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